Sofosbuvir and velpatasvir is a combination antiviral medicine used to treat chronic hepatitis C in adults and children at least 3 years old. This medicine may be used with ribavirin.

Sofosbuvir and velpatasvir treats specific genotypes of hepatitis C, and only in certain people. Your doctor will perform tests to make sure sofosbuvir and velpatasvir is the right treatment for you.

Sofosbuvir and velpatasvir is sometimes used in people who also have HIV, but this medicine does not treat HIV or AIDS.

Sofosbuvir and velpatasvir may also be used for purposes not listed in this medication guide.

This medicine is sometimes used in combination with other antiviral medication. Read the medication guide or patient instructions provided with each medication in your combination therapy.

When taking sofosbuvir and velpatasvir with other medicine: Tell your doctor about all your medical conditions, and if you are pregnant or breastfeeding.

Tell your doctor if you have ever had:

• hepatitis B;
• liver problems other than hepatitis C;
• kidney disease (or if you are on dialysis);
• diabetes;
• HIV (human immunodeficiency virus); or
• if you use a blood thinner (warfarin, Coumadin, Jantoven) and you have routine "INR" or prothrombin time tests.

Sofosbuvir and velpatasvir is sometimes used in combination with ribavirin. Both men and women using ribavirin should use birth control to prevent pregnancy. Ribavirin can harm an unborn baby if the mother or father is using ribavirin. Keep using birth control for at least 6 months after your last dose of ribavirin. Tell your doctor right away if a pregnancy occurs.

Ask a doctor if it is safe to breastfeed while using these medicines.

Use Sofosbuvir And Velpatasvir (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have new or worsening symptoms such as:

• right-sided upper stomach pain;
• vomiting, loss of appetite, not feeling well; or
• jaundice (yellowing of the skin or eyes).

If you also take a heart rhythm medicine called amiodarone: Taking amiodarone with sofosbuvir and velpatasvir can cause dangerous side effects on your heart. Get medical help right away if you take this medicine and you have:

• very slow heartbeats, chest pain, shortness of breath;
• confusion, memory problems; or
• weakness, extreme tiredness, light-headed feeling (like you might pass out).

Common side effects may include:

• headache, tiredness;
• nausea, vomiting, diarrhea;
• sleep problems (insomnia); or
• low red blood cells (anemia) in people with cirrhosis--pale skin, tiredness, feeling light-headed or short of breath, cold hands and feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.