Pregnancy & Lactation: Risk data not available
What is Sofosbuvir, Velpatasvir, And Voxilaprevir?
Sofosbuvir, velpatasvir, and voxilaprevir (Vosevi) is a combination antiviral medicine that is used to treat chronic hepatitis C in adults.
Vosevi treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.
Vosevi is sometimes used in people who also have HIV. Vosevi is not a treatment for HIV or AIDS.
Vosevi may also be used for purposes not listed in this medication guide.
Warnings
You should not use this medicine if you are allergic to sofosbuvir, velpatasvir, or voxilaprevir.
Tell your doctor if you have ever had:
- hepatitis B;
- liver problems other than hepatitis C;
- kidney disease (or if you are on dialysis); or
- if you use a blood thinner (warfarin, Coumadin, Jantoven) and you have routine "INR" or prothrombin time tests.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
How should I use Sofosbuvir, Velpatasvir, And Voxilaprevir
Use Sofosbuvir, Velpatasvir, And Voxilaprevir (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using this medicine.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Vosevi is usually taken once per day for 12 weeks.
Take this medicine with food, at the same time each day.
You will need frequent blood tests to check your liver function.
If you've ever had hepatitis B, using Vosevi can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.
You should not stop using Vosevi suddenly. Stopping suddenly could make your hepatitis C harder to treat with antiviral medicine.
Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with chronic hepatitis C should remain under the care of a doctor.
Store this medicine in the original container at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Get your prescription refilled before you run out of medicine completely.
Sofosbuvir, Velpatasvir, And Voxilaprevir side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
In rare cases, Vosevi may cause serious liver injury. Call your doctor right away if you have symptoms such:
- right-sided upper stomach pain;
- nausea, vomiting, loss of appetite;
- confusion, tiredness, feeling light-headed;
- easy bruising or bleeding, vomiting blood;
- diarrhea, black or bloody stools;
- dark urine; or
- yellowing of your skin or eyes.
If you also take a heart rhythm medicine called amiodarone: Taking amiodarone with Vosevi can cause dangerous side effects on your heart. Get medical help right away if you take these medicines and you have:
- very slow heartbeats, chest pain, shortness of breath;
- confusion, memory problems; or
- weakness, extreme tiredness, light-headed feeling (like you might pass out).
Common side effects may include:
- headache;
- feeling tired; or
- nausea, diarrhea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Sofosbuvir, Velpatasvir, And Voxilaprevir?
If you also take an antacid, do not take it for at least 4 hours after you have taken your dose of Vosevi (with food).
Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.