Desmopressin is a man-made form of a hormone that occurs naturally in the pituitary gland. This hormone affects blood pressure, kidney function, and regulating how the body uses water.

Desmopressin nasal is used to treat central cranial diabetes insipidus, and increased thirst and urination caused by head surgery or head trauma.

Stimate is used to treat bleeding episodes in people with hemophilia A or von Willebrand's disease Type I.

Noctiva is used to treat excessive night-time urination in adults who are at least 50 years old. Noctiva should not be used to treat night-time bedwetting.

Desmopressin nasal may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to desmopressin.

Depending on your condition, you may not be able to use desmopressin nasal if you have:

• a history of hyponatremia (low sodium levels in your body);
• uncontrolled high blood pressure;
• congestive heart failure;
• moderate to severe kidney disease;
• SIADH (syndrome of inappropriate antidiuretic hormone secretion); or
• a fever, infection, vomiting, diarrhea or any other condition that can cause excessive thirst, dehydration, or an electrolyte imbalance.

Some medicines can cause unwanted or dangerous effects when used with desmopressin nasal. Your doctor may need to change your treatment plan if you also use:

• a "loop" diuretic (water pill)--bumetanide, ethacrynic acid, furosemide, torsemide; or
• an oral, inhaled, or injectable steroid medicine--budesonide, dexamethasone, fluticasone, mometasone, prednisone, and many others.

Desmopressin nasal may be less effective if you have any swelling or scarring inside your nose, or any nasal or sinus problems (such as deviated septum).

Tell your doctor if you have:

• nasal problems such as a runny or stuffy nose;
• a psychologic disorder that causes extreme or unusual thirst;
• an infection or illness with fever, vomiting, or diarrhea;
• congestive heart failure, coronary artery disease;
• kidney disease or being unable to urinate;
• a head injury or brain tumor;
• cystic fibrosis; or
• diabetes.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Desmopressin nasal should not be used to treat excessive urination that is a normal condition of pregnancy.

It may not be safe to breastfeed a baby while you are using this medicine. Ask your doctor about any risks.

Do not give this medicine to a child without medical advice.

Use Stimate (Nasal) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• signs of low sodium--headache, confusion, hallucinations, muscle pain or weakness, drowsiness, vomiting, loss of appetite, and feeling restless or irritable;
• rapid weight gain, swelling in your feet or ankles;
• a seizure (convulsions); or
• nasal problems--runny or stuffy nose, sinus congestion.

Low sodium may be more likely to occur in children and older adults.

Common side effects may include:

• stuffy nose, runny nose, sinus pain, sneezing, nosebleeds, discomfort in your nose;
• sore throat, cough;
• dizziness;
• increased blood pressure;
• nausea, stomach cramps;
• headache, back pain; or
• flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

To help prevent night-time urination, avoid drinking a lot of liquid close to bedtime.