By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Multikinase inhibitors > Stivarga
Multikinase inhibitors

Stivarga

https://themeditary.com/drug/stivarga-3196.html
Medically Reviewed by Sanjai Sinha, MD TheMediTary.Com | Reviewed: Jul 14, 2023  Additional Content by TheMediTary.Com

Generic name: regorafenib [ re-goe-raf-e-nib ]

Drug class: Multikinase inhibitors, VEGF/VEGFR inhibitors

Dosage form: tablet, film coated

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Regorafenib

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Stivarga?

Stivarga is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Stivarga is used to treat colorectal cancer and liver cancer. It is also used to treat a rare type of tumor that can affect the esophagus, stomach, or intestines.

Stivarga is usually given after other cancer medications have been tried without success.

Warnings

Stivarga can cause serious or life-threatening liver problems. Call your doctor at once if you have nausea, vomiting, sleep problems, dark urine, or jaundice (yellowing of the skin or eyes).

You should not use Stivarga if past use has caused severe bleeding or severe liver problems.

Use birth control to prevent pregnancy, whether you are a man or a woman. Avoid pregnancy for at least 2 months after you stop using this medicine.

Before taking this medicine

To make sure Stivarga is safe for you, tell your doctor if you have:

  • liver disease;

  • high blood pressure;

  • a bleeding or blood clotting disorder;

  • heart disease, chest pain; or

  • if you recently had surgery or plan to have surgery.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Regorafenib can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 2 months after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Stivarga.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

Stivarga pregnancy and breastfeeding warnings (more detail)

How should I take Stivarga

Take Stivarga exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Stivarga is usually taken daily for 3 weeks followed by 1 week off the medicine. Your doctor will determine how many times you should repeat this treatment cycle.

Stivarga works best if you take it after a low-fat, low-calorie meal. Swallow the tablet whole with a full glass of water.

Take the medicine at the same time each day.

Your blood pressure will need to be checked often. Your liver function will also need to be checked.

If you need surgery, tell your surgeon you currently use this medicine. Stivarga can cause problems with wounds healing, including surgical incisions. You should stop taking this medicine at least 2 weeks before you have surgery. Carefully follow your doctor's instructions about when to stop and start taking Stivarga.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative. Do not put Stivarga tablets into a daily pill box.

Throw away any Stivarga tablets not used within 7 weeks after opening the bottle.

Dosing information

Usual Adult Dose for Colorectal Cancer:

160 mg orally once a day for the first 21 days of each 28-day cycle
-Lowest Dose: 80 mg per day
-Duration of Therapy: Until disease progression or unacceptable toxicity

Uses: Treatment of:
-Metastatic colorectal cancer previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and an anti-EGFR therapy if RAS wild-type.
-Locally advanced, unresectable or metastatic gastrointestinal stromal tumor previously treated with imatinib mesylate and sunitinib malate.
-Hepatocellular carcinoma previously treated with sorafenib.

Usual Adult Dose for Gastrointestinal Stromal Tumor:

160 mg orally once a day for the first 21 days of each 28-day cycle
-Lowest Dose: 80 mg per day
-Duration of Therapy: Until disease progression or unacceptable toxicity

Uses: Treatment of:
-Metastatic colorectal cancer previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and an anti-EGFR therapy if RAS wild-type.
-Locally advanced, unresectable or metastatic gastrointestinal stromal tumor previously treated with imatinib mesylate and sunitinib malate.
-Hepatocellular carcinoma previously treated with sorafenib.

Usual Adult Dose for Hepatocellular Carcinoma:

160 mg orally once a day for the first 21 days of each 28-day cycle
-Lowest Dose: 80 mg per day
-Duration of Therapy: Until disease progression or unacceptable toxicity

Uses: Treatment of:
-Metastatic colorectal cancer previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and an anti-EGFR therapy if RAS wild-type.
-Locally advanced, unresectable or metastatic gastrointestinal stromal tumor previously treated with imatinib mesylate and sunitinib malate.
-Hepatocellular carcinoma previously treated with sorafenib.

Detailed Stivarga dosage information
Stivarga Dosage information (more detail)

Before Taking

To make sure Stivarga is safe for you, tell your doctor if you have:

  • liver disease;

  • high blood pressure;

  • a bleeding or blood clotting disorder;

  • heart disease, chest pain; or

  • if you recently had surgery or plan to have surgery.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Regorafenib can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 2 months after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Stivarga.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

Stivarga pregnancy and breastfeeding warnings (more detail)

Related/similar drugs

Keytruda, Avastin, capecitabine, fluorouracil, pembrolizumab, Xeloda, imatinib

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Stivarga?

Grapefruit and grapefruit juice may interact with regorafenib and lead to potentially dangerous effects. Avoid the use of grapefruit products while taking regorafenib.

Avoid taking an herbal supplement containing St. John's wort.

Stivarga side effects

Get emergency medical help if you have signs of an allergic reaction to Stivarga (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stivarga can cause serious or life-threatening liver problems. Call your doctor at once if you have nausea, vomiting, sleep problems, dark urine, or jaundice (yellowing of the skin or eyes).

Also call your doctor at once if you have:

  • headache, confusion, change in mental status;

  • vision changes;

  • a seizure;

  • pain, blisters, bleeding, or severe rash in the palms of your hands or the soles of your feet;

  • heart problems - chest pain, shortness of breath, feeling like you might pass out;

  • increased blood pressure - severe headache, blurred vision, pounding in your neck or ears;

  • perforation (a hole or tear) in your stomach or intestines - fever, chills, severe stomach pain or swelling, nausea, vomiting, increased thirst, decreased urination;

  • severe bleeding - bruising, nosebleeds, heavy menstrual periods or abnormal vaginal bleeding, blood in your urine, bloody or tarry stools, coughing up blood, or any bleeding that will not stop; or

  • signs of infection - fever, sore throat, feeling short of breath, cough with or without mucus, vaginal itching or discharge, pain or burning when you urinate, or redness and swelling anywhere in your body.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common Stivarga side effects may include:

  • diarrhea, nausea, stomach pain;

  • loss of appetite, weight loss;

  • increased blood pressure;

  • fever, infection;

  • abnormal liver function tests;

  • pain or redness in your mouth or throat, hoarse voice; or

  • feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Stivarga Side Effects

What other drugs will affect Stivarga?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can interact with regorafenib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

More about Stivarga (Regorafenib [ re-goe-raf-e-nib ])

Dosage information
Stivarga Side Effects
During pregnancy
Stivarga Prescribing Information
Drug images
Side effects
Drug class: Multikinase inhibitors

Related treatment guides

Gastrointestinal Stromal Tumor
Hepatocellular Carcinoma
Colorectal Cancer
Share this Article
Contents
Uses Warnings Before Taking Dosage Side effects Interactions
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by