Talazoparib is used in adults to treat certain type of breast cancer that has spread to other parts of the body.

Talazoparib is also used in adults in combination with other drugs to treat prostate cancer that has spread to other parts of the body and when surgery or other treatments to decrease testosterone levels have not worked.

Your doctor will make sure you have the correct tumor type to be treated with talazoparib.

Talazoparib may also be used for purposes not listed in this medication guide.

Tell your doctor if you have or have ever had:

• kidney disease.

Using talazoparib may increase your risk of developing bone marrow problems or leukemia. Ask your doctor about your individual risk.

Talazoparib can harm an unborn baby if the mother or the father is using this medicine.

• If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 7 months after your last dose.
• If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
• Tell your doctor right away if a pregnancy occurs.

It may be harder for you to get a woman pregnant while you are using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

Use Talzenna Liquid-Filled (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• blood in your urine or stools;
• easy bruising, unusual bleeding, purple or red spots under your skin;
• weight loss;
• frequent infections;
• low red blood cells (anemia)--pale skin, weakness, tiredness, feeling light-headed or short of breath, cold hands and feet; or
• low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• low blood cell counts;
• an electrolyte imbalance (such as low blood levels of potassium or magnesium);
• bone injuries, low levels of calcium in your blood (hypocalcemia);
• high levels of bilirubin in the blood;
• high blood sugar;
• changes in your sense of taste
• nausea, vomiting, diarrhea, loss of appetite;
• hair loss;
• dizziness, headache; or
• feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.