Tbo-filgrastim is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection.

Tbo-filgrastim is used to reduce the duration of severe neutropenia, a lack of certain white blood cells caused by receiving chemotherapy with certain cancer medications.

Tbo-filgrastim is for use in adults and children who are least 1 month old.

Tbo-filgrastim may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to filgrastim (Neupogen) or pegfilgrastim (Neulasta).

Tell your doctor if you have ever had:

• a hemoglobin blood cell disorder such as sickle cell anemia, thalassemia;
• kidney disease; or
• if you are scheduled to have radiation treatment, a bone scan, or other medical tests.

Using a G-CSF such as tbo-filgrastim can cause your spleen to rupture, which can be fatal. Talk with your doctor if you have concerns about this risk.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

Use Tbo-Filgrastim (Subcutaneous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, difficult breathing; fast heart rate, sweating, feeling light-headed; swelling in your face, lips, tongue, or throat.

Capillary leak syndrome is a rare but serious side effect of tbo-filgrastim. Call your doctor right away if you have signs of this condition: stuffy or runny nose followed by weakness or tired feeling, and sudden swelling in your arms, legs and other parts of the body.

Call your doctor at once if you have:

• stomach pain, back pain;
• a general ill feeling;
• signs of a kidney problem--blood in your urine, swelling in your face or ankles, little or no urination;
• signs of infection--fever, redness, or swelling;
• signs of acute respiratory distress syndrome--fever with shortness of breath or trouble breathing; or
• signs of a ruptured spleen--pain in your upper stomach spreading to your left shoulder.

Common side effects may include:

• bone pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid injecting this medicine into skin that is red, bruised, scarred, tender, or hard.

Avoid getting this medicine in your eyes. If contact does occur, rinse with water.