Tildrakizumab reduces the effects of a substance in the body that can cause inflammation.

Tildrakizumab is used to treat moderate to severe psoriasis in adults.

Tildrakizumab may also be used for purposes not listed in this medication guide.

Tildrakizumab affects your immune system. You may get infections more easily. Call your doctor if you have a fever, chills, aches, cough, shortness of breath, skin sores, diarrhea, weight loss, or burning when you urinate.

Before you start treatment with tildrakizumab, your doctor may perform tests to make sure you do not have tuberculosis or other infections.

Tildrakizumab is injected under the skin.

A healthcare provider will give you this injection.

Usual Adult Dose for Plaque Psoriasis:

100 mg subcutaneously at Weeks 0 and 4, and every 12 weeks thereafter

Comments:
-Evaluate patients for tuberculosis (TB) infection prior to initiating therapy.

Use: For adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy

You should not be treated with tildrakizumab if you are allergic to it.

Tell your doctor if you have a chronic infection, or if you are scheduled to receive any vaccine.

Tell your doctor if you have ever had tuberculosis or if anyone in your household has tuberculosis.

It is not known whether tildrakizumab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

Tildrakizumab is not approved for use by anyone younger than 18 years old.

Call your doctor for instructions if you miss an appointment for your tildrakizumab injection.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Do not receive a "live" vaccine while using tildrakizumab. The vaccine may not work as well and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:

• fever, chills, sweating;

• skin sores;

• muscle pain;

• increased urination, pain or burning when you urinate;

• stomach pain, diarrhea, weight loss; or

• cough, shortness of breath, coughing up pink or red mucus.

Common side effects of tildrakizumab may include:

• pain, itching, rash, redness, swelling, bruising, or bleeding where the medicine was injected;

• diarrhea; or

• cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Other drugs may affect tildrakizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.