Tipiracil and trifluridine is a combination cancer medicine used to treat colorectal cancer, or cancer of the stomach and lower esophagus.

This medicine is used when the cancer has spread to other parts of the body (metastatic).

Tipiracil and trifluridine is usually given after other treatments have failed.

Tipiracil and trifluridine may also be used for purposes not listed in this medication guide.

Tell your doctor if you have ever had:

• kidney disease; or
• liver disease.

You may need to have a negative pregnancy test before starting this treatment.

Tipiracil and trifluridine can harm an unborn baby if the mother or the father is using this medicine.

• If you are a woman, do not use tipiracil and trifluridine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using tipiracil and trifluridine.

You should not breastfeed while using this medicine, and for at least 24 hours after your last dose.

Use Tipiracil And Trifluridine (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• low levels of platelets in your blood--easy bruising, unusual bleeding, purple or red spots under your skin;
• low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
• low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Serious side effects may be more likely in older adults.

Common side effects may include:

• stomach pain, loss of appetite;
• nausea, vomiting, diarrhea;
• fever; or
• feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.