Generic name: tizanidine [ tye-zan-i-deen ]
Drug class: Skeletal muscle relaxants
Availability: Prescription only
Pregnancy & Lactation: Risk data available
Brand names: Zanaflex
What is Tizanidine?
Tizanidine is a short-acting muscle relaxer. It works by blocking nerve impulses (pain sensations) that are sent to your brain.
Tizanidine is used to treat spasticity by temporarily relaxing muscle tone.
Tizanidine may also be used for purposes not listed in this medication guide.
Warnings
Tizanidine is a short-acting medication that should be taken only for daily activities that require relief from muscle spasticity.
You should not take tizanidine if you are also taking fluvoxamine (Luvox) or ciprofloxacin (Cipro).
Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.
Switching between tablets and capsules, or changing the way you take it with regard to eating, can cause an increase in side effects or a decrease in therapeutic effect. Follow your doctor's instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects.
The recommended starting dose of tizanidine is 2 mg every 6 to 8 hours, up to a maximum of 3 doses in 24 hours. Do not take more than 36 mg of tizanidine in a 24-hour period. Too much of this medicine can damage your liver. Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine.
Avoid drinking alcohol. It can increase some of the side effects of this medicine.
Before taking this medicine
You should not use tizanidine if you are allergic to it, or if:
-
you also take the antidepressant fluvoxamine (Luvox); or
-
you also take the antibiotic ciprofloxacin (Cipro).
To make sure tizanidine is safe for you, tell your doctor if you have ever had:
-
liver disease;
-
kidney disease; or
-
low blood pressure.
It is not known whether tizanidine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
How should I take Tizanidine
Tizanidine comes as a tablet and a capsule to take by mouth. It is usually taken consistently either always with or always without food two or three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tizanidine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Tizanidine capsules may be opened and sprinkled on soft foods such as applesauce. Talk to your doctor before opening the capsules because the effects of the medication when used in this manner may be different than when swallowing the capsule whole.
The medication in the capsule is absorbed differently by the body than the medication in the tablet, so one product cannot be substituted for the other. Each time you have your prescription filled, look at the tablets or capsules in the bottle and make sure that you have received the right product. If you think you received the wrong medication, talk to your doctor or pharmacist right away.
Your doctor will probably start you on a low dose of tizanidine and gradually increase your dose, depending on your response to this medication.
Do not stop taking tizanidine without talking to your doctor. If you suddenly stop taking tizanidine, your heart may beat faster and you may have increased blood pressure or tightness in your muscles. Your doctor will probably decrease your dose gradually.
Dosing information
Take tizanidine exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Tizanidine is usually taken up to 3 times in one day, starting at 2mg per dose. Allow 6 to 8 hours to pass between doses. Do not take more than 36 mg in a 24-hour period. Too much of this medicine can damage your liver.
You may take tizanidine with or without food, but take it the same way each time. Switching between taking with food and taking it without food can make the medicine less effective or cause increased side effects.
Switching between tablets and capsules may cause changes in side effects or how well the medicine works.
-
Taking the tablets with food can increase your blood levels of tizanidine.
-
Taking the capsules with food can decrease your blood levels of tizanidine.
If you make any changes in how you take tizanidine, tell your doctor if you notice any change in side effects or in how well the medicine works.
Tizanidine is a short-acting medication, and its effects will be most noticeable between 1 and 3 hours after you take it. You should take this medicine only for daily activities that require relief from muscle spasms.
You will need frequent blood tests to check your liver function.
If you stop using this medicine suddenly after long-term use, you may have withdrawal symptoms such as dizziness, fast heartbeats, tremors, and anxiety. Ask your doctor how to safely stop using this medicine.
Store at room temperature away from moisture and heat.
Before Taking
You should not use tizanidine if you are allergic to it, or if:
-
you also take the antidepressant fluvoxamine (Luvox); or
-
you also take the antibiotic ciprofloxacin (Cipro).
To make sure tizanidine is safe for you, tell your doctor if you have ever had:
-
liver disease;
-
kidney disease; or
-
low blood pressure.
It is not known whether tizanidine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Related/similar drugs
cyclobenzaprine, baclofen, diazepam, methocarbamol, Flexeril, SomaWhat happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include weakness, drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, or fainting.
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I avoid while using Tizanidine?
Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may be dangerous for you to have reduced muscle tone.
Drinking alcohol with this medicine can cause side effects.
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Tizanidine side effects
Get emergency medical help if you have signs of an allergic reaction to tizanidine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
-
a light-headed feeling, like you might pass out;
-
weak or shallow breathing;
-
confusion, hallucinations; or
-
pain or burning when you urinate.
Common tizanidine side effects may include:
-
drowsiness, dizziness, weakness;
-
feeling nervous;
-
blurred vision;
-
flu-like symptoms;
-
dry mouth, trouble speaking;
-
abnormal liver function tests;
-
runny nose, sore throat;
-
urination problems, painful urination;
-
vomiting, constipation; or
-
uncontrolled muscle movements.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See more: Tizanidine Side EffectsWhat other drugs will affect Tizanidine?
Taking tizanidine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Tell your doctor about all your other medicines, especially:
-
acyclovir;
-
ticlopidine;
-
zileuton;
-
birth control pills;
-
an antibiotic - ciprofloxacin, levofloxacin, moxifloxacin, or ofloxacin;
-
blood pressure medicine - clonidine, guanfacine, methyldopa;
-
heart rhythm medicine - amiodarone, mexiletine, propafenone, verapamil; or
-
stomach acid medicine - cimetidine, famotidine.
This list is not complete. Other drugs may interact with tizanidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to tizanidine.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
What to Expect
Tizanidine usually starts to work within one to two hours and wears off after about six to eight hours.
This medicine can make you feel sleepy, dizzy, or weak. Be sure to take it at a time when you don’t have to be alert. Let your doctor know if you experience any unusual side effects while using tizanidine.
If you’ve taken tizanidine for awhile, don’t stop using it suddenly without first talking to your doctor.
Additional Dosage Information
Your dosage will be based on your medical condition and how you respond to treatment.
You can take tizanidine every six to eight hours, but you shouldn’t take more than three doses in 24 hours (36 milligrams a day).
Secondary Uses
Tizanidine is sometimes prescribed “off-label” to treat the following:
- Migraine headaches
- Insomnia
- Analgesic withdrawal