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Home > Drugs > Miscellaneous coagulation modifiers > Tranexamic acid
Miscellaneous coagulation modifiers

Tranexamic acid

https://themeditary.com/drug/tranexamic-acid-5637.html
Medically Reviewed by Oluni Odunlami, MD TheMediTary.Com | Reviewed: Aug 12, 2023  Additional Content by TheMediTary.Com

Generic name: tranexamic acid (cyklokapron) [ tran-ex-am-ik-as-id ]

Drug class: Miscellaneous coagulation modifiers

Dosage form: intravenous solution (10 mg/ml-nacl 0.7%; 100 mg/ml)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Cyklokapron, Lysteda, Tranexamic acid (lysteda)

Contents
Uses Warnings Before Taking Dosage Side effects Interactions
  • Tranexamic acid (Tranexamic acid (cyklokapron) [ tran-ex-am-ik-as-id ])-WPI 3720-650 mg-White-Oval Tranexamic acid 650 mg (WPI 3720)
  • Tranexamic acid (Tranexamic acid (cyklokapron) [ tran-ex-am-ik-as-id ])-XP650-650 mg-White-Oval Tranexamic acid 650 mg (XP650)
  • Tranexamic acid (Tranexamic acid (cyklokapron) [ tran-ex-am-ik-as-id ])-APO TRA 650-650 mg-White-Oval Tranexamic acid 650 mg (APO TRA 650)
  • Tranexamic acid (Tranexamic acid (cyklokapron) [ tran-ex-am-ik-as-id ])-FP650-650 mg-White-Oval Tranexamic acid 650 mg (FP650)
  • View all images

What is Tranexamic acid?

Tranexamic acid prevents enzymes in the body from breaking down blood clots.

Cyklokapron is used to prevent bleeding in people with hemophilia who need to have a tooth pulled. This medication is usually given just before the dental procedure, and daily for up to 8 days afterward.

Tranexamic acid may also be used for purposes not listed in this medication guide.

Warnings

You should not use Cyklokapron if you are color blind, if you have problems with the blood vessels in your eyes, or if you have ever had a stroke, blood clot, or bleeding in your brain.

How should I take Tranexamic acid

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Cyklokapron is given as an infusion into a vein just before your tooth is pulled. You may need to keep using this medicine for up to 8 days afterward.

A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Your vision may need to be tested while you are using tranexamic acid.

Store this medicine at room temperature. Prepare an injection only when you are ready to give it.

Each vial or ampule is for one use only. Throw it away after one use, even if there is still medicine left inside.

Dosing information

Usual Adult Dose for Bleeding:

Initial dose: 10 mg/kg intravenously, immediately before dental extraction
Maintenance dose: 10 mg/kg intravenously three to four times daily
Duration of therapy: 2 to 8 days

Comments: Infuse no more than 1 mL/minute to avoid hypotension.

Use: Short-term use in patients with hemophilia to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following a tooth extraction.

Usual Adult Dose for Menstrual Disorders:

Dose: 1300 mg (two 650 mg tablets) orally three times a day (3900 mg/day) during monthly menstruation
Duration: Maximum of 5 days

Use: For the treatment of cyclic heavy menstrual bleeding

Usual Pediatric Dose for Bleeding:

Initial dose: 10 mg/kg intravenously, immediately before dental extraction
Maintenance dose: 10 mg/kg intravenously three to four times daily
Duration of therapy: 2 to 8 days

Comments:
-The limited data suggest that dosing instructions for adults can be used for pediatric patients needing therapy for tooth extractions.
-Infuse no more than 1 mL/minute to avoid hypotension.

Use: Short-term use in patients with hemophilia to reduce or prevent hemorrhage and reduce the need for replacement therapy during tooth extractions.

Usual Pediatric Dose for Menstrual Disorders:

Post menarchal females:

Dose: 1300 mg (two 650 mg tablets) orally three times a day (3900 mg/day) during monthly menstruation

Duration: Maximum of 5 days

Use: For the treatment of cyclic heavy menstrual bleeding in post-menarchal females

Detailed Tranexamic acid dosage information
Tranexamic acid Dosage information (more detail)

Before Taking

You should not use Cyklokapron if you are allergic to tranexamic acid, or if you have:

  • problems with the blood vessels in your eyes;

  • color blindness (only if you are receiving the injectable form of tranexamic acid); or

  • a history of stroke, blood clot, or bleeding in your brain.

Tell your doctor if you have ever had:

  • kidney disease;

  • a bladder or kidney infection; or

  • leukemia.

Tell your doctor if you are pregnant or breastfeeding.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, confusion, vision problems, vomiting, diarrhea, numbness or weakness, problems with speech or balance, feeling light-headed, or fainting.

What should I avoid while using Tranexamic acid?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Tranexamic acid side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Cyklokapron may cause serious side effects. Stop using Cyklokapron and call your doctor at once if you have:

  • problems with your vision (including color vision);

  • a light-headed feeling, like you might pass out;

  • a seizure;

  • painful or difficult urination, blood in your urine;

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems;

  • signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or

  • signs of a blood clot in your leg--swelling, warmth, or redness in an arm or leg.

Common side effects include:

  • nausea, vomiting, diarrhea;

  • dizziness, feeling light-headed;

  • mild itching or rash; or

  • feeling unusually happy.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Tranexamic acid Side Effects

What other drugs will affect Tranexamic acid?

Tell your doctor about all your other medicines, especially:

  • any type of medication to treat a bleeding episode or a blood clot; or

  • factor IX complex (Bebulin, Bebulin VH, Profilnine, and others).

This list is not complete. Other drugs may affect Cyklokapron, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about Tranexamic acid (Tranexamic acid (cyklokapron) [ tran-ex-am-ik-as-id ])

Dosage information
Tranexamic acid Side Effects
During pregnancy
Drug images
Side effects
Breastfeeding Warnings
Drug class: Miscellaneous coagulation modifiers

Patient resources

Tranexamic Acid Tablets

Related treatment guides

Bleeding Disorder
Heavy Menstrual Bleeding
Menstrual Disorders
Hemophilia A
Factor IX Deficiency
Melasma
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Contents
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