By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Antidiabetic combinations > Trijardy xr
Antidiabetic combinations

Trijardy xr

https://themeditary.com/drug/trijardy-xr-3446.html
Medically Reviewed by Judith Stewart, BPharm TheMediTary.Com | Reviewed: Jul 14, 2023  Additional Content by TheMediTary.Com

Generic name: empagliflozin, linagliptin, and metformin [ em-pa-gli-floe-zin, lin-a-glip-tin, and-met-for-min ]

Drug class: Antidiabetic combinations

Dosage form: oral tablet, extended release (10 mg-5 mg-1000 mg; 12.5 mg-2.5 mg-1000 mg; 25 mg-5 mg-1000 mg; 5 mg-2.5 mg-1000 mg)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Empagliflozin, linagliptin, and metformin

Contents
Uses Warnings Before Taking Dosage Side effects Interactions
  • Trijardy xr (Empagliflozin, linagliptin, and metformin [ em-pa-gli-floe-zin, lin-a-glip-tin, and-met-for-min ])-BI Logo 395 5/2.5-empagliflozin 5 mg / linagliptin 2.5 mg / metformin hydrochloride 1000 mg extended-release-Gray-Oval Trijardy xr empagliflozin 5 mg / linagliptin 2.5 mg / metformin hydrochloride 1000 mg extended-release (BI Logo 395 5/2.5)
  • Trijardy xr (Empagliflozin, linagliptin, and metformin [ em-pa-gli-floe-zin, lin-a-glip-tin, and-met-for-min ])-BI Logo 380 10/5-empagliflozin 10 mg / linagliptin 5 mg / metformin hydrochloride 1000 mg extended-release-Tan-Oval Trijardy xr empagliflozin 10 mg / linagliptin 5 mg / metformin hydrochloride 1000 mg extended-release (BI Logo 380 10/5)
  • Trijardy xr (Empagliflozin, linagliptin, and metformin [ em-pa-gli-floe-zin, lin-a-glip-tin, and-met-for-min ])-BI Logo 385 12.5/2.5-empagliflozin 12.5 mg / linagliptin 2.5 mg / metformin hydrochloride 1000 mg extended-release-Red-Oval Trijardy xr empagliflozin 12.5 mg / linagliptin 2.5 mg / metformin hydrochloride 1000 mg extended-release (BI Logo 385 12.5/2.5)
  • Trijardy xr (Empagliflozin, linagliptin, and metformin [ em-pa-gli-floe-zin, lin-a-glip-tin, and-met-for-min ])-BI Logo 390 25/5-empagliflozin 25 mg / linagliptin 5 mg / metformin hydrochloride 1000 mg extended-release-Brown-Oval Trijardy xr empagliflozin 25 mg / linagliptin 5 mg / metformin hydrochloride 1000 mg extended-release (BI Logo 390 25/5)
  • View all images

What is Trijardy xr?

Trijardy XR tablets contains a comination of empagliflozin, linagliptin, and metformin. Empagliflozin, linagliptin, and metformin are all oral diabetes medicines that help control blood sugar levels.

Trijardy XR is a prescription medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Trijardy XR is also used to lower the risk of death from heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease.

Trijardy XR is not for treating type 1 diabetes.

Warnings

You should not use Trijardy XR if you have severe kidney disease (or if you are on dialysis) or diabetic ketoacidosis, or if you have ever had a severe allergic reaction to metformin, empagliflozin or linagliptin.

Call your doctor at once if you have signs of a serious side effect, such as severe pain in your upper stomach spreading to your back, vomiting, fast heart rate, dizziness, feeling very thirsty or hot, decreased urination, heavy sweating, or hot and dry skin.

Tell your doctor if you are sick with vomiting or diarrhea, or if you eat or drink less than usual.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

In rare cases, Trijardy XR can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.

How should I take Trijardy xr

Take Trijardy XR exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Trijardy XR is usually taken in the morning with a meal.

Swallow the tablet whole and do not crush, chew, break, or dissolve it. Tell your doctor if you have trouble swallowing the tablet.

Part of the Trijardy XR tablet shell may appear in your stool but this will not make the medicine less effective.

Your blood sugar will need to be checked often, and you may also need to test the level of ketones in your urine. Empagliflozin can cause life-threatening ketoacidosis (too much acid in the blood). Even if your blood sugar is normal, contact your doctor if a urine test shows that you have high ketones in the urine.

Blood sugar can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals.

Low blood sugar (hypoglycemia) can make you feel very hungry, dizzy, irritable, or shaky. To quickly treat hypoglycemia, eat or drink hard candy, crackers, raisins, fruit juice, or non-diet soda. Your doctor may prescribe glucagon injection in case of severe hypoglycemia.

Tell your doctor if you have frequent symptoms of high blood sugar (hyperglycemia) such as increased thirst or urination. Ask your doctor before changing your medication dosage.

You may get dehydrated during prolonged illness. Call your doctor if you are sick with vomiting or diarrhea, or if you eat or drink less than usual.

Trijardy XR can affect the results of certain medical tests. Tell any doctor who treats you that you are using Trijardy XR.

Your doctor may have you take extra vitamin B12 while you are taking Trijardy XR. Take only the amount of vitamin B12 your doctor has prescribed.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose of Trijardy XR for Diabetes Type 2:

Individualize initial dose based on the patient's current regimen:
-For patients on metformin, with or without linagliptin: Initiate with a similar metformin dose plus empagliflozin 10 mg and linagliptin 5 mg orally once a day
-For patients on metformin and any regimen containing empagliflozin, with or without linagliptin: Initiate with a similar dose of metformin, the same empagliflozin dose, and linagliptin 5 mg orally once a day

Monitor effectiveness and tolerability and adjust dose as appropriate not to exceed maximum doses
-Maximum doses: Empagliflozin 25 mg/day; Linagliptin 5 mg/day; Metformin 2000 mg/day

Comments:
-When used in combination with insulin or an insulin secretagogue, a lower dose of insulin or insulin secretagogue should be considered to reduce the risk of hypoglycemia.
-Correct volume depletion prior to beginning therapy.
-Trijardy XR is not recommended in patients with type 1 diabetes mellitus; it may increase the risk of ketoacidosis in these patients.
-This drug has not been studied in patients with a history of pancreatitis and therefore it is unknown if patients with a history of pancreatitis are at an increased risk for developing pancreatitis while using this drug.

Uses:
-As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
-Empagliflozin is indicated to reduce the risk of cardiovascular (CV) death in adults with type 2 diabetes mellitus and established CV disease.

Detailed Trijardy XR dosage information
Trijardy xr Dosage information (more detail)

Before Taking

You should not use Trijardy XR if you are allergic to empagliflozin, linagliptin, or metformin, or if you have:

  • severe kidney disease (or if you are on dialysis);

  • a history of severe allergic or skin reaction after taking linagliptin; or

  • metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Trijardy XR. Be sure your caregivers know ahead of time that you are using Trijardy XR.

To make sure Trijardy XR is safe for you, tell your doctor if you have ever had:

  • liver or kidney disease;

  • a bladder infection or urination problems;

  • a pancreas disorder;

  • congestive heart failure, a heart attack or stroke;

  • gallstones;

  • a genital infection (penis or vagina);

  • alcoholism, or if you currently drink large amounts of alcohol;

  • high cholesterol or triglycerides;

  • if you are on a low salt diet; or

  • if you are 65 or older.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Ask your doctor about your risk.

Follow your doctor's instructions about using Trijardy XR if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy.

You should not use Trijardy XR during the second or third trimester of pregnancy.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

Do not breastfeed while you are taking Trijardy XR.

Trijardy XR is not approved for use by anyone younger than 18 years old.

Trijardy XR pregnancy and breastfeeding warnings (more detail)

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

An overdose of Trijardy XR may cause lactic acidosis. Symptoms may include unusual muscle pain, trouble breathing, irregular heartbeats, or if you feel very weak.

What should I avoid while using Trijardy xr?

Avoid drinking alcohol. It may increase your risk of lactic acidosis.

Trijardy xr side effects

Get emergency medical help if you have signs of an allergic reaction to Trijardy XR: hives, itching, flaking or peeling skin; trouble swallowing, difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have signs of a serious genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.

Stop taking Trijardy XR and call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • severe or ongoing pain in your joints;

  • lactic acidosis - unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired;

  • serious skin reaction - itching, blisters, breakdown of the outer layer of skin;

  • ketoacidosis (too much acid in the blood) - nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing;

  • pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting;

  • dehydration - dizziness, confusion, feeling very thirsty, less urination;

  • signs of a bladder infection - pain or burning when you urinate, blood in your urine, pain in pelvis or back; or

  • symptoms of heart failure - shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain.

Common Trijardy XR side effects may include:

  • stomach pain, diarrhea, constipation;

  • a bladder infection;

  • headache; or

  • cold symptoms such as runny or stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Trijardy xr Side Effects

What other drugs will affect Trijardy xr?

Other drugs may increase or decrease the effects of Trijardy XR on lowering your blood sugar. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • insulin, or other oral diabetes medicine;

  • rifampin (to treat tuberculosis); or

  • a diuretic or "water pill."

This list is not complete. Other drugs may interact with empagliflozin, linagliptin, and metformin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about Trijardy xr (Empagliflozin, linagliptin, and metformin [ em-pa-gli-floe-zin, lin-a-glip-tin, and-met-for-min ])

Dosage information
Trijardy xr Side Effects
During pregnancy
Trijardy XR Prescribing Information
Drug images
Side effects
Drug class: Antidiabetic combinations

Related treatment guides

Diabetes, Type 2
Share this Article
Contents
Uses Warnings Before Taking Dosage Side effects Interactions
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by