Capivasertib is used in combination with fulvestrant to treat hormone-related breast cancer.

Capivasertib is used when the cancer has progressed, spread to other parts of the body (metastatic), or after other treatments did not work or stopped working.

Your doctor will make sure you have the correct tumor type to be treated with capivasertib.

Capivasertib may also be used for purposes not listed in this medication guide.

You should not use capivasertib if you are allergic to it.

Tell your doctor if you have or ever had:

• high blood sugar levels, type 1 or type 2 diabetes, if you use insulin;
• rash or other skin problems; or
• liver disease.

Capivasertib can harm an unborn baby if the mother or the father is using this medicine.

• If you are a woman, you will need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 1 month after your last dose.
• If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
• Tell your doctor right away if a pregnancy occurs.

Do not breastfeed while using this medicine.

Use Truqap (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Call your doctor at once if you have:

• redness, new or worsening rash, or blisters on the palms of your hands or the soles of your feet;
• severe stomach pain, diarrhea that is watery or bloody;
• high blood sugar--increased urination, dry mouth, fruity breath odor, nausea, vomiting, appetite or weight changes; or
• dehydration--dizziness, confusion, feeling very thirsty, less urination.

Your cancer treatments may change, be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• nausea, vomiting, or diarrhea;
• abnormal blood tests;
• blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or
• tiredness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Grapefruit may interact with capivasertib and cause side effects. Avoid consuming grapefruit products.