Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Hydrocodone is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex.

Chlorpheniramine and hydrocodone is a combination medicine used to treat runny nose, sneezing, itching, watery eyes, and cough caused by allergies, the common cold, or the flu.

Chlorpheniramine and hydrocodone may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to chlorpheniramine or hydrocodone.

Do not use chlorpheniramine and hydrocodone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Do not give this medicine to a child younger than 6 years old. Chlorpheniramine and hydrocodone is not approved for use by anyone younger than 18 years old.

Tell your doctor if you have ever had:

• asthma or other breathing problems;
• seizures, or a head injury or brain tumor;
• a blockage in your digestive tract (stomach or intestines);
• enlarged prostate, urination problems;
• low blood pressure;
• liver or kidney disease;
• Addison's disease (an adrenal gland disorder);
• problems with your thyroid, gallbladder, or pancreas; or
• alcoholism or drug addiction.

If you use hydrocodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using chlorpheniramine and hydrocodone.

Use Tussionex Pennkinetic (Chlorpheniramine And Hydrocodone) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Like other narcotic medications, hydrocodone can slow your breathing. Death may occur if breathing becomes too weak.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop using this medicine and call your doctor at once if you have:

• severe drowsiness;
• noisy breathing, sighing, shallow breathing;
• severe constipation;
• a light-headed feeling, like you might pass out;
• a slow heart rate or weak pulse;
• confusion; or
• adrenal gland problems--nausea, vomiting, loss of appetite, dizziness, feeling weak or tired.

Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.

Common side effects may include:

• trouble breathing;
• drowsiness;
• confusion;
• nausea, vomiting; or
• little or no urination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Ask a doctor or pharmacist before using other cough or cold medicines that may contain similar ingredients.