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Home > Drugs > CGRP inhibitors > Ubrogepant
CGRP inhibitors

Ubrogepant

https://themeditary.com/drug/ubrogepant-5788.html
Medically Reviewed by Melisa Puckey, BPharm TheMediTary.Com | Reviewed: Aug 12, 2023  Additional Content by TheMediTary.Com

Generic name: ubrogepant

Drug class: CGRP inhibitors

Dosage form: tablet

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Ubrelvy

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Ubrogepant?

Ubrogepant is a tablet used by adults to treat migraine headaches, it does not prevent migraines.

It was approved by the FDA in 2019 as studies showed that two hours after patients took ubrogepant, they had less pain and more freedom from their most bothersome migraine symptoms (eg. nausea, light sensitivity and sound sensitivity), when compared to other patients taking a placebo (dummy pill).

It is from the class of drugs called calcitonin gene-related peptide (CGRP) receptor antagonists. CGRP is a protein in the nerve endings that is involved in pain and migraines. Ubrogepant blocks the CGRP protein from attaching to the nerve endings and so decreases the pain and migraine symptoms

What is ubrogepant used for?

  • ubrogepant is a prescription medicine used for the acute treatment of migraine attacks with or without aura in adults.
  • it is not used to prevent migraine headaches.
  • It is not known if this medicine is safe and effective in children.

How should I take Ubrogepant

Ubrogepant comes as a tablet to take by mouth. It is usually taken at the first sign of a migraine headache. If your symptoms improve after you take ubrogepant but return after 2 hours or longer, your doctor may tell you that you may take a second tablet. Talk to your doctor to see if you may take a second dose if needed. Your doctor will tell you the maximum number of tablets you may take in a 24-hour period. Your doctor will also tell you the maximum number of migraine headaches you should treat with ubrogepant tablets in a 30-day period. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ubrogepant exactly as directed. Do not take more or less of it or take it more often than directed by the package label or prescribed by your doctor.

Call your doctor if your headaches do not get better or occur more frequently after taking ubrogepant.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Dosing information

Take ubrogepant exactly as your healthcare provider tells you to take it.

You can take your ubrogepant tablet with or without food.

Most patients can take a second tablet 2 hours after the first tablet, as needed.

You should not take a second tablet within 24 hours if you consume grapefruit or grapefruit juice or are taking medications that may include:

  • Verapamil
  • Cyclosporine
  • Ciprofloxacin
  • Fluconazole
  • fluvoxamine

It is not known if it is safe to take ubrogepant for more than 8 migraine headaches in 30 days.

You should write down when you have headaches and when you take ubrogepant so you can talk to your healthcare provider about how ubrogepant is working for you.

If you take too much ubrogepant, call your healthcare provider or go to the nearest hospital emergency room right away.

Detailed Ubrogepant dosage information
Ubrogepant Dosage information (more detail)

Before Taking

Do not take ubrogepant if you are taking medicines known as a strong CYP3A4 inhibitor, such as:

  • ketoconazole
  • clarithromycin
  • itraconazole

Ask your healthcare provider if you are not sure if you are taking any of these medicines. Your healthcare provider can tell you if it is safe to take ubrogepant with other medicines.

Ubrogepant pregnancy and breastfeeding warnings (more detail)

Related/similar drugs

Ubrelvy, Botox, diclofenac, celecoxib, sumatriptan, metoclopramide, Reglan

What should I tell my doctor before taking ubrogepant ?

Before you take ubrogepant tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems
  • have kidney problems
  • are pregnant or plan to become pregnant. It is not known if ubrogepant will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if ubrogepant passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. See the interactions section below about specific medications that interact with ubrogepant.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Do not take a second ubrogepant tablet within 24 hours of taking the first dose if you drink grapefruit juice or eat grapefruit. Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.

Ubrogepant side effects

The most common side effects of ubrogepant are nausea and sleepiness.

These are not all of the possible side effects of this medicine. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Ubrogepant Side Effects

What other drugs will affect Ubrogepant?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you take any of the following, as your healthcare provider may need to change the dose of ubrogepant:

  • Verapamil
  • cyclosporine
  • ciprofloxacin
  • Fluconazole
  • fluvoxamine
  • Phenytoin
  • Barbiturates
  • Rifampin
  • St. John’s Wort
  • Quinidine
  • Carvedilol
  • Eltrombopag
  • curcumin

These are not all of the medicines that could affect how ubrogepant works. Your healthcare provider can tell you if it is safe to take ubrogepant with other medicines.

What other information should I know?

Keep all appointments with your doctor.

You should keep a headache diary by writing down when you have headaches and when you take ubrogepant.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

More about Ubrogepant (Ubrogepant)

Dosage information
Ubrogepant Side Effects
During pregnancy
Drug images
Side effects
Breastfeeding Warnings
Drug class: CGRP inhibitors

Related treatment guides

Migraine
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