Selexipag is used to treat pulmonary arterial hypertension (PAH). Selexipag helps keep your condition from getting worse and helps lower your risk of needing to be hospitalized for PAH.

Selexipag may also be used for purposes not listed in this medication guide.

You should not use selexipag if you are allergic to it.

Some drugs should not be used with selexipag. Your treatment plan may change if you also use:

• clopidogrel; or
• gemfibrozil.

Tell your doctor if you have ever had:

• a condition called pulmonary veno-occlusive disease (narrowing of the veins that carry blood from the lungs to the heart); or
• liver disease.

It is not known if selexipag will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed.

Use Uptravi Titration Pack (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• low red blood cells (anemia)--pale skin, tiredness, feeling light-headed or short of breath, cold hands and feet; or
• new lung problems--anxiety, sweating, pale skin, severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus, chest pain, fast or uneven heart rate.

Common side effects may include:

• headache;
• jaw pain;
• muscle pain, pain in your arms or legs;
• joint pain;
• flushing (warmth, redness, or tingly feeling);
• rash;
• anemia;
• nausea, vomiting, loss of appetite, diarrhea; or
• pain, redness, or swelling where a selexipag injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.