By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Vasopressin antagonists > Vaprisol
Vasopressin antagonists

Vaprisol

https://themeditary.com/drug/vaprisol-4054.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 05, 2023  Additional Content by TheMediTary.Com

Generic name: conivaptan [ koe-nye-vap-tan ]

Drug class: Vasopressin antagonists

Dosage form: injection, solution

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Conivaptan

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Vaprisol?

Vaprisol is a vasopressin antagonist that reduces the level of a hormone that regulates the balance of water and salt (sodium) in the body. High levels of this hormone can cause an imbalance that results in low sodium levels and fluid retention.

Vaprisol is used to treat hyponatremia (low sodium levels).

Vaprisol improves urine flow without causing the body to lose too much sodium as you urinate.

Warnings

You should not receive Vaprisol if you are allergic to corn products, or if you are unable to urinate.

Serious drug interactions can occur when certain medicines are used together. Tell your doctor about all your current medicines and any you start or stop using.

Before you receive Vaprisol, tell your doctor if you have congestive heart failure, liver disease, kidney disease, alcoholism, or if you are malnourished.

To be sure Vaprisol is helping your condition, your blood will need to be tested often. Tell your caregivers at once if you have a serious side effect such as confusion, extreme thirst, muscle weakness or limp feeling, trouble speaking or swallowing, mood changes, or swelling or discomfort where the IV needle is placed. There are many other drugs that should not be used together with conivaptan, including certain antibiotics or antifungal medicines, heart or blood pressure medication, and HIV/AIDS medicine.

How should I take Vaprisol

Vaprisol is injected into a vein through an IV. You will receive this injection in a hospital setting.

Vaprisol is infused around-the-clock for 2 to 4 days. This medication is usually given only in a hospital.

You may have very low blood pressure while taking this medicine. Tell your caregivers if you feel weak, tired, dizzy, or very light-headed, or if you have any diarrhea or vomiting.

Because conivaptan can irritate the skin or vein when the medicine enters the body, your IV needle will be moved to a different vein every 24 hours.

To be sure this medicine is helping your condition, your blood will need to be tested often.

Dosing information

Usual Adult Dose for Hyponatremia:

Initial dose: Loading dose of 20 mg IV once over 30 minutes; followed by 20 mg continuous IV infusion over 24 hours
-Following initial day of treatment, administer 20 mg continuous IV infusion over 24 hours for an additional 1 to 3 days; may titrate to a maximum of 40 mg continuous IV infusion over 24 hours if serum sodium is not rising at the desired rate

Comments:
-The total duration of infusion (after the loading dose) should not exceed 4 days.
-Frequently monitor serum sodium and volume status during administration.

Use: To raise serum sodium in hospitalized patients with euvolemic or hypervolemic hyponatremia

Usual Adult Dose for Hyponatremia, euvolemic:

Initial dose: Loading dose of 20 mg IV once over 30 minutes; followed by 20 mg continuous IV infusion over 24 hours
-Following initial day of treatment, administer 20 mg continuous IV infusion over 24 hours for an additional 1 to 3 days; may titrate to a maximum of 40 mg continuous IV infusion over 24 hours if serum sodium is not rising at the desired rate

Comments:
-The total duration of infusion (after the loading dose) should not exceed 4 days.
-Frequently monitor serum sodium and volume status during administration.

Use: To raise serum sodium in hospitalized patients with euvolemic or hypervolemic hyponatremia

Detailed Vaprisol dosage information
Vaprisol Dosage information (more detail)

Before Taking

You should not receive Vaprisol if you are allergic to corn products, or if you are unable to urinate.

Some medicines can cause unwanted or dangerous effects when used with Vaprisol. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • lomitapide;

  • medicine to treat depression or mental illness - nefazodone, lurasidone, pimozide;

  • an antibiotic - clarithromycin, erythromycin, telithromycin;

  • antifungal medicine - itraconazole, ketoconazole, voriconazole;

  • heart or blood pressure medicine - dronedarone, eplerenone, nimodipine, ranolazine;

  • HIV/AIDS medicine - atazanavir, cobicistat, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, ritonavir;

  • medicine to treat hepatitis C - boceprevir, telaprevir; or

  • prostate medicine - alfuzosin, silodosin.

To make sure Vaprisol is safe for you, tell your doctor if you have:

  • congestive heart failure;

  • liver disease;

  • kidney disease;

  • alcoholism;

  • HIV or AIDS;

  • malnourishment; or

  • a condition for which you take digoxin (digitalis).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Vaprisol may affect fertility (ability to have children) in women.

It is not known whether conivaptan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are receiving Vaprisol.

Vaprisol pregnancy and breastfeeding warnings (more detail)

What happens if I miss a dose?

Since Vaprisol is given by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while using Vaprisol?

Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Vaprisol side effects

Get emergency medical help if you have signs of an allergic reaction to Vaprisol: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have:

  • a light-headed feeling, like you might pass out;

  • low potassium - confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling; or

  • signs of a rapid increase in sodium levels - trouble speaking, trouble swallowing, weakness, mood changes, muscle spasm or weakness in your arms and legs, seizure.

Common Vaprisol side effects may include:

  • fever;

  • low potassium;

  • headache, mild dizziness; or

  • pain, redness, or swelling around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Vaprisol Side Effects

What other drugs will affect Vaprisol?

Many drugs can interact with conivaptan, and some drugs should not be used together. You may need to wait at least 1 week after your last dose of Vaprisol before you can begin taking certain other medicines. Ask your doctor about your specific treatment plan.

Not all possible interactions are listed in this medication guide. Tell your doctor about all your medications and any you start or stop using during treatment with Vaprisol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

More about Vaprisol (Conivaptan [ koe-nye-vap-tan ])

Dosage information
Vaprisol Side Effects
During pregnancy
Vaprisol Prescribing Information
Drug images
Side effects
Drug class: Vasopressin antagonists

Related treatment guides

SIADH
Euvolemic Hyponatremia
Share this Article
Contents
Uses Warnings Before Taking Dosage Side effects Interactions
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by