Venastat is a plant also known as Aescin, Aesculus hippocastanum, Buckeye, Castaño de Indias, Châtaignier de Mer, Châtaignier des Chevaux, Escine, Faux-Châtaignier, Hippocastani, Hippocastanum Vulgare Gaertn, Marron Europeen, Marronnier, Spanish Chestnut, Venostasin Retard, Venostat, White Chestnut, and other names.

Venastat has been used in alternative medicine and is likely effective in treating some symptoms of chronic venous insufficiency (decreased blood flow return from the feet and legs back to the heart). These symptoms include leg pain or tenderness, varicose veins, itching or swelling in the legs, and fluid retention (puffy or swollen ankles or feet).

Other uses not proven with research have included fever, cough, diarrhea, hemorrhoids, enlarged prostate, menstrual cramps, and swelling caused by arthritis, sprains, or bone fractures.

It is not certain whether Venastat is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. This medicine should not be used in place of medication prescribed for you by your doctor.

Venastat is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Venastat may also be used for purposes not listed in this product guide.

Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.

If you choose to use Venastat, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.

The usual dose of horse chestnut in capsule form is 1 capsule every 12 hours before a meal.

Take the capsule with a full glass of water.

Do not crush, chew, break, or open a Venastat capsule. Swallow it whole.

It is best to use a Venastat product that contains an exact amount of the labeled chemical. Check the label to be sure your product does not contain a toxic substance called "esculin."

It may take up to 4 weeks before your symptoms improve. Call your doctor if your symptoms do not improve, or if they get worse while using Venastat.

Store at room temperature away from moisture, heat, and light.

Before using Venastat, talk to your healthcare provider. You may not be able to use this medicine if you have certain medical conditions, such as:

• a bleeding or blood clotting disorder (Venastat can thin your blood);

• diabetes (Venastat may cause low blood sugar);

• kidney disease;

• liver disease;

• a stomach or intestinal disorder;

• congestive heart disease;

• epilepsy;

• asthma;

• migraine headaches; or

• if you are allergic to latex.

It is not known whether Venastat will harm an unborn baby. Do not use this product if you are pregnant.

Horse chestnut may pass into breast milk and may harm a nursing baby. Do not use this product if you are breast-feeding a baby.

Do not give any herbal/health supplement to a child without medical advice.

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra Venastat to make up the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. The use of raw Venastat (seeds, flowers, stems, leaves) can cause fatal poisoning.

Signs of horse chestnut poisoning may include weakness, depressed mood, loss of coordination, dilated pupils, vomiting, diarrhea, little or no urinating, muscle twitching, or loss of movement in any part of the body.

Avoid the use of raw Venastat seed, bark, flower, or leaves. These items are not safe to take by mouth and may cause fatal side effects.

Avoid using Venastat together with other herbal/health supplements that can lower blood sugar, such as alpha-lipoic acid, chromium, devil's claw, fenugreek, garlic, guar gum, Panax ginseng, psyllium, Siberian ginseng, and others.

Avoid using Venastat together with herbal/health supplements that can also affect blood-clotting. This includes angelica (dong quai), capsicum, clove, danshen, garlic, ginger, ginkgo, panax ginseng, poplar, red clover, turmeric, and willow.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Although not all side effects are known, Venastat is thought to be possibly safe when taken for a short period of time.

Stop using Venastat and call your healthcare provider at once if you have:

• severe skin redness, swelling, itching, or rash.

Common side effects of Venastat may include:

• upset stomach;

• headache, dizziness; or

• itching

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not take Venastat without medical advice if you are using any of the following medications:

• insulin or oral diabetes medicine;

• medicines to prevent blood clots--clopidogrel (Plavix), dalteparin, enoxaparin, heparin, warfarin (Coumadin, Jantoven), and others; or

• an NSAID (nonsteroidal anti-inflammatory drug)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with horse chestnut, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this product guide.