Vevye is a solution of cyclosporine 0.1% that may be used in the eyes to treat the signs and symptoms of dry eye disease. It is supplied as eye drops.

Vevye works by reducing the underlying inflammation associated with dry eye disease that interferes with tear production. Cyclosporine is a calcineurin inhibitor immunosuppressant.

Dry eye disease is an inflammatory ocular surface disorder that can cause progressive corneal surface damage that can lead to direct or indirect visual impairment.

Vevye is formulated with EyeSol®, a water-free technology that allows for increased absorption of cyclosporin onto the surface of the eye and a longer-lasting effect.

Vevye was approved by the FDA on May 30, 2023.

Do not touch the Vevye dropper on any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated (dirty), it could cause an infection in the eye(s).

Do not use this medicine while wearing contact lenses. Contact lenses may be reinserted 15 minutes following the administration of Vevye eye drops unless otherwise directed by your doctor.

Use Vevye eye drops exactly as directed by your doctor. Follow all directions on your prescription label and medication guide. Do not use the eye drops in larger or smaller amounts or for longer than recommended.

• Wash your hands before using the eye drops.
• The usual dose is 1 drop into each eye twice daily, approximately 12 hours apart.
• If used with other eye drops then allow a 15-minute interval between products.

You should not use Vevye if you are allergic to cyclosporine.

It is not known if using Vevye eye drops during pregnancy is safe. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether Vevye passes into breast milk or if it could harm a nursing baby, although it is likely safe. Tell your doctor if you are breastfeeding a baby.

This medicine is not approved for use for children and young adults younger than 18 years old.

Instil the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not use extra medicine to make up for the missed dose.

An overdose of Vevye is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

You should not put Vevye in your eyes while wearing contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses. It may be best not to wear contact lenses if you have dry eyes. Talk with your doctor about your own risk.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated (dirty) dropper can infect your eye, which could lead to serious vision problems.

Get emergency medical help if you have signs of an allergic reaction to Vevye such as hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

• eye pain; or
• eye swelling, redness, severe discomfort, crusting, or drainage (may be signs of infection).

Common Vevye side effects may include instillation site reactions such as:

• mild burning or stinging in the eyes
• mild redness or itching
• blurred vision or
• feeling like something is in your eye.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.