Vinblastine is used to treat Hodgkin's disease, certain types of lymphoma, testicular cancer, breast cancer, choriocarcinoma (a type of uterine cancer), Kaposi's sarcoma, and Letterer-Siwe disease.

Vinblastine is often used in combination with other cancer drugs.

Vinblastine may also be used for purposes not listed in this medication guide.

You should not be treated with vinblastine if you have severely low white blood cell counts, or an uncontrolled bacterial infection.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when vinblastine is injected.

Vinblastine comes as a powder or solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given once a week. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have.

Your doctor may need to delay your treatment or change your dose if you experience certain side effects. It is important for you to tell your doctor how you are feeling during your treatment with vinblastine injection.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Vinblastine is given as an infusion into a vein, usually once every 7 days. A healthcare provider will give you this injection.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when vinblastine is injected.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.

Vinblastine may cause constipation. Ask your doctor how to avoid severe constipation.

You should not receive vinblastine if you are allergic to it, or if you have:

• severely low white blood cell counts; or

• an untreated or uncontrolled bacterial infection.

Tell your doctor if you have ever had:

• breathing problems;

• coronary artery disease, a blood clot or stroke (including "mini-stroke");

• liver disease;

• wasting syndrome (decreased weight with loss of muscle tissue);

• skin ulcers, bed sores; or

• cancer than has spread to your bone marrow.

Vinblastine may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant. vinblastine may cause missed menstrual periods.

This medicine may affect fertility (ability to have children) in men.

You should not breastfeed while using this medicine.

Call your doctor for instructions if you miss an appointment for your vinblastine injection.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Since vinblastine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. However, overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

Unless your doctor tells you otherwise, continue your normal diet.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Vinblastine may cause serious side effects. Call your doctor at once if you have:

• wheezing, trouble breathing;

• chest pain or pressure, pain spreading to your jaw or shoulder;

• severe constipation;

• ongoing nausea or vomiting;

• numbness, tingling, burning pain;

• problems with vision, hearing, speech, balance, or daily activities;

• mouth pain or ulcers; or

• low blood cell counts--fever, chills, sore throat, body aches, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects of vinblastine may include:

• low blood cell counts;

• jaw pain, tumor pain, bone pain;

• constipation; or

• temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tell your doctor about all your other medicines, especially:

• nefazodone;

• phenytoin;

• an antibiotic--clarithromycin, erythromycin, telithromycin;

• antifungal medicine--itraconazole, ketoconazole, posaconazole, voriconazole; or

• antiviral medicine to treat HIV or hepatitis C--boceprevir, cobicistat, dasabuvir, elvitegravir, indinavir, lopinavir/ritonavir, nelfinavir, ombitasvir, paritaprevir saquinavir, telaprevir, tipranavir.

This list is not complete. Other drugs may affect vinblastine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to vinblastine.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.