Vincristine liposome is used to treat a type of blood cancer called Philadelphia chromosome negative acute lymphoblastic leukemia (ALL).

Vincristine liposome is given after at least two other cancer treatments did not work or have stopped working.

Vincristine liposome may also be used for purposes not listed in this medication guide.

You should not use vincristine liposome if you are allergic to it, or if you have Charcot-Marie-Tooth syndrome or other conditions that cause damage to myelin (protective covering of the nerves in your brain and spinal cord).

Tell your doctor if you have ever had:

• liver disease;
• a nerve-muscle disorder such as myasthenia gravis, ALS (Lou Gehrig's disease), multiple sclerosis, or muscular dystrophy;
• a bowel obstruction called paralytic ileus; or
• peripheral vascular disease such as Raynaud's syndrome.

Vincristine liposome may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

You should not breastfeed while using vincristine liposome. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby. Follow your doctor's instructions about when you can start breastfeeding again after your treatment ends.

Use Vincristine Liposome (Marqibo) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• severe constipation, stomach pain, bloating;
• severe ongoing nausea, vomiting, or diarrhea;
• numbness, tingling, weakness, or burning pain in your hands or feet;
• severe tiredness;
• low blood cell counts--fever, chills, cough, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or
• signs of tumor cell breakdown--tiredness, weakness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth.

Common side effects may include:

• fever, low blood cell counts;
• tiredness;
• numbness, tingling;
• diarrhea, constipation,
• nausea, loss of appetite; or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.