Vitrase is a genetically designed protein.

Vitrase is used together with fluids injected into the body to treat dehydration. Hyaluronidase can also be used as an aid in helping your body absorb other injected medications.

Vitrase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.

Serious drug interactions can occur when certain medicines are used together with Vitrase. Tell your doctor about all your current medicines.

Before receiving Vitrase, tell your doctor if you are using any of the following drugs: furosemide (Lasix); phenytoin (Dilantin); a sedative or anxiety medication (such as Valium, Xanax, Tranxene); aspirin or salicylates; cortisone or ACTH (Corticotropin); estrogens; or an antihistamine (such as a cold or allergy medicine).

Your doctor may perform a skin test before using Vitrase to see if you are allergic to hyaluronidase.

Before receiving this medicine

You should not be treated with Vitrase if you are allergic to hyaluronidase.

Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication.

Some medicines can cause unwanted or dangerous effects when used with hyaluronidase. Your doctor may need to change your treatment plan if you use any of the following drugs:

• furosemide (Lasix);

• phenytoin (Dilantin);

• a sedative or anxiety medication (such as diazepam, lorazepam, alprazolam, Valium, Xanax, Ativan, Tranxene, and others);

• aspirin or salicylates;

• cortisone or ACTH (Corticotropin);

• estrogens; or

• an antihistamine (such as a cold or allergy medicine).

Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using Vitrase. Ask your doctor about any risk.

Vitrase is injected under the skin, into a muscle, or into other tissues of the body.

A healthcare provider will administer your Vitrase injection.

Vitrase should not be injected into a vein (as an intravenous injection).

You should not be treated with Vitrase if you are allergic to hyaluronidase.

Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication.

Some medicines can cause unwanted or dangerous effects when used with hyaluronidase. Your doctor may need to change your treatment plan if you use any of the following drugs:

• furosemide (Lasix);

• phenytoin (Dilantin);

• a sedative or anxiety medication (such as diazepam, lorazepam, alprazolam, Valium, Xanax, Ativan, Tranxene, and others);

• aspirin or salicylates;

• cortisone or ACTH (Corticotropin);

• estrogens; or

• an antihistamine (such as a cold or allergy medicine).

Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using Vitrase. Ask your doctor about any risk.

Because you will receive Vitrase in a clinical setting, you are not likely to miss a dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Get emergency medical help if you have signs of an allergic reaction ro Vitrase: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you experience any of the following common Vitrase side effects:

• swelling in your hands, feet, or other body areas; or

• pain, swelling, itching, or redness where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Other drugs may interact with hyaluronidase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.