Voriconazole is an antifungal medicine that is used to treat infections caused by yeast or other types of fungus.

Voriconazole may also be used for purposes not listed in this medication guide.

You should not use voriconazole if you are allergic to it.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with voriconazole. Your doctor may change your treatment plan if you also use:

• carbamazepine;
• cisapride;
• efavirenz;
• ivabradine;
• lurasidone;
• naloxegol;
• pimozide;
• quinidine;
• rifabutin, rifampin;
• ritonavir;
• sirolimus;
• St. John's wort;
• tolvaptan;
• venetoclax;
• certain barbiturates (mephobarbital, phenobarbital); or
• "ergot" migraine headache medicines (dihydroergotamine, ergotamine, ergonovine, methylergonovine).

Tell your doctor if you have ever had:

• heart disease, or a heart rhythm disorder;
• high or low levels of calcium, potassium, or magnesium in your blood;
• liver or kidney disease; or
• trouble digesting sugar or dairy products (voriconazole tablets contain lactose, voriconazole liquid contains sucrose).

Voriconazole may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

Voriconazole can interact with certain birth control pills, which may increase side effects. Ask your doctor about the best form of birth control to use during treatment with voriconazole.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Voriconazole is not approved for use by anyone younger than 2 years old.

Use Voriconazole (VFEND) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Call your doctor at once if you have:

• fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
• a sunburn;
• vision problems, changes in your color vision;
• easy bruising, unusual bleeding, purple or red spots under your skin;
• slow heart rate, weak pulse, fainting, slow breathing;
• increased adrenal gland hormones--hunger, weight gain, swelling, skin discoloration, slow wound healing, sweating, acne, increased body hair, mood changes, muscle weakness, missed menstrual periods, sexual changes;
• decreased adrenal gland hormones--stomach pain, loss of appetite, feeling light-headed, muscle or joint pain, skin discoloration, craving salty foods;
• kidney problems--little or no urination, swelling in your feet or ankles;
• liver problems--nausea, vomiting, flu-like symptoms, itching, tiredness, or jaundice (yellowing of the skin or eyes); or
• signs of an electrolyte imbalance--dizziness, numbness or tingling, constipation, increased thirst or urination, irregular heartbeats, cough or choking feeling, feeling jittery, leg cramps, muscle spasms, muscle weakness or limp feeling.

Common side effects may include:

• fever, chills, stuffy nose, sneezing, sinus pain, cough, sore throat, trouble breathing;
• bruising or bleeding, nosebleeds, coughing up blood;
• high or low blood pressure, fast heart rate;
• electrolyte imbalance;
• stomach pain, bloating, nausea, vomiting, diarrhea, constipation;
• kidney problems;
• swelling in your hands or feet;
• headache, dizziness, vision changes, hallucinations;
• rash; or
• abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Voriconazole may cause vision changes such as blurred vision and sensitivity to light. Wear sunglasses during the day to protect your eyes from bright light. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Avoid exposure to sunlight or tanning beds. Voriconazole can make you more sensitive to sunlight or cause a serious skin reaction, including lesions that may lead to skin cancer. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.