Selinexor is used together with bortezomib and/or dexamethasone to treat multiple myeloma in adults.

Selinexor is also used in adults to treat certain types of diffuse large B-cell lymphoma.

Selinexor is given after other medications did not work or have stopped working.

Selinexor was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed.

Selinexor may also be used for purposes not listed in this medication guide.

Tell your doctor if you have ever had:

• cataracts;
• bleeding problems; or
• an active or recent infection.

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Selinexor can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 1 week after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using selinexor.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because selinexor can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Not approved for use by anyone younger than 18 years old.

Use Xpovio 60 Mg Once-Weekly (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Selinexor can cause serious or fatal side effects. Some side effects may not occur until you have been taking this medicine for several days or weeks.

Call your doctor at once if you have:

• blurred vision, tunnel vision, eye pain, or seeing halos around lights;
• severe ongoing nausea, vomiting, or diarrhea;
• loss of appetite that prevents you from eating and causes weight loss;
• confusion, dizziness, fainting, or changes in mental status;
• symptoms of sepsis--fever or chills, severe drowsiness, fast heartbeats, rapid breathing, feeling very ill;
• signs of infection--fever, chills, flu symptoms, cough with mucus, mouth and throat ulcers, feeling short of breath, tingly or painful blistering rash on one side of your body; or
• low sodium level--headache, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Your treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• double vision, blurred vision, sensitivity to light or glare;
• tiredness;
• numbness, tingling, or burning pain in your hands or feet;
• anemia, bruising or bleeding;
• increased blood sugar;
• fever, infections, cold or flu symptoms;
• changes in sodium and mineral levels;
• abnormal liver or kidney function tests;
• nausea, vomiting, loss of appetite;
• diarrhea, constipation;
• weight loss; or
• shortness of breath.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.