Applies to econazole topical: topical cream, topical foam.

Serious side effects of Econazole topical

Along with its needed effects, econazole topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking econazole topical:

Less common

• Burning, itching, stinging, redness, or other sign of irritation at the application site
• rash

For Healthcare Professionals

Applies to econazole topical: compounding powder, topical cream, topical foam.

Dermatologic

Topical Cream:

-Common (1% to 10%): Pruritus/itching, skin burning sensation/burning, erythema

-Frequency not reported: Pruritic rash

-Postmarketing reports: Angioedema, contact dermatitis, rash, urticaria, blister, skin exfoliation

Vaginal Cream and Pessaries:

-Common (1% to 10%): Pruritus, skin burning sensation

-Uncommon (0.1% to 1%): Rash

-Rare (0.01% to 0.1%): Erythema

-Postmarketing reports: Angioedema, urticaria, contact dermatitis, skin exfoliation^[Ref]

Other

Topical Cream:

-Common (1% to 10%): Pain/stinging

-Uncommon (0.1% to 1%): Discomfort, swelling^[Ref]

Genitourinary

Vaginal Cream and Pessaries:

-Uncommon (0.1% to 1%): Vulvovaginal burning sensation^[Ref]

Local

One patient developed erythematous, edematous, urticarial-like lesions with vesiculation at the site of drug application. Sensitivity to this drug was confirmed by patch testing.^[Ref]

Topical Cream:

-Frequency not reported: Lesions with vesiculation at site of application

Topical Foam:

-Uncommon (0.1% to 1%): Application site reactions

Vaginal Cream and Pessaries:

-Postmarketing reports: Application site pain, application site irritation, application site swelling^[Ref]

Hypersensitivity

Topical Cream:

-Frequency not reported: Drug sensitivity

-Postmarketing reports: Hypersensitivity

Vaginal Cream and Pessaries:

-Postmarketing reports: Hypersensitivity^[Ref]