Note: This document contains side effect information about sacubitril / valsartan. Some dosage forms listed on this page may not apply to the brand name Entresto.
Summary
Common side effects of Entresto include: hyperkalemia, hypotension, and increased serum creatinine. Other side effects include: acute kidney injury, and renal failure syndrome. Continue reading for a comprehensive list of adverse effects.
Applies to sacubitril / valsartan: oral tablet.
Warning
Oral route (Tablet)
Drugs that act directly on the renin-angiotensin system may cause fetal injury or death. Discontinue use immediately if pregnancy is detected.
Serious side effects of Entresto
Along with its needed effects, sacubitril/valsartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking sacubitril / valsartan:
More common
- Abdominal or stomach pain
- blurred vision
- confusion
- difficult breathing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- irregular heartbeat
- nausea or vomiting
- nervousness
- numbness or tingling in the hands, feet, or lips
- sweating
- unusual tiredness or weakness
- weakness or heaviness of the legs
Less common
- Bloody urine
- decreased frequency or amount of urine
- increased thirst
- loss of appetite
- lower back or side pain
- swelling of the face, fingers, or lower legs
- weight gain
Rare
- Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
Other side effects of Entresto
Some side effects of sacubitril / valsartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Cough
- dizziness
For Healthcare Professionals
Applies to sacubitril / valsartan: oral tablet.
General
The most common adverse reactions were hypotension, hyperkalemia, cough, dizziness, and renal failure.[Ref]
Cardiovascular
Very common (10% or more): Hypotension (18%)
Common (1% to 10%): Orthostasis[Ref]
Metabolic
Very common (10% or more): Potassium greater than 5.5 mEq/L (16%), hyperkalemia (12%)[Ref]
Renal
Very common (10% or more): Serum creatinine increased greater than 50% (16%)
Common (1% to 10%): Renal failure/acute renal failure[Ref]
Respiratory
Common (1% to 10%): Cough[Ref]
Nervous system
Common (1% to 10%): Dizziness[Ref]
Dermatologic
Uncommon (0.1% to 1%): Angioedema
Postmarketing reports: Rash, pruritus[Ref]
The incidence of angioedema was 2.4% in Black patients.[Ref]
Hematologic
Common (1% to 10%): Hemoglobin/hematocrit decreased greater than 20%[Ref]
Other
Common (1% to 10%): Falls[Ref]
Immunologic
Postmarketing reports: Hypersensitivity, anaphylactic reaction
