Applies to ephedrine: oral fixed-dose combination with guaifenesin, parenteral injection.

Side effects include:

Parenteral ephedrine: Nervousness, insomnia, vertigo, headache, tachycardia, palpitation, sweating, nausea, vomiting, anorexia, vesical sphincter spasm (resulting in difficult and painful urination), urinary retention (particularly in males with prostatism).

For Healthcare Professionals

Applies to ephedrine: compounding powder, injectable solution, intravenous solution, oral capsule, oral tablet.

General

The most frequently reported side effects were nausea, vomiting, and tachycardia.^[Ref]

Cardiovascular

Very rare (less than 0.01%): Myocardial infarction

Frequency not reported: Tachycardia, palpitations, reactive hypertension, bradycardia, ventricular ectopics, R-R variability, pallor, angina/anginal pain, hypertension, hypotension, extrasystole, arrhythmias, vasodilation with low blood pressure, flushing, impaired circulation to extremities^[Ref]

Genitourinary

Frequency not reported: Difficult/painful urination, acute urinary retention^[Ref]

Nervous system

Frequency not reported: Dizziness, headache, trembling, lightheadedness, tremor, sedation^[Ref]

Respiratory

Frequency not reported: Dry nose, dry throat, shortness of breath, respiratory difficulty, dyspnea, respiratory depression^[Ref]

Psychiatric

Frequency not reported: Restlessness, addiction, nervousness, anxiety, insomnia, mood/mental changes, fear, irritability, confusion, delirium, euphoria, psychotic states, tension, hallucinations^[Ref]

Other

Frequency not reported: Fever, precordial pain, vertigo, tachyphylaxis, drug tolerance, drug dependence, weakness^[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, dry mouth, mild epigastric distress, hypersalivation^[Ref]

Metabolic

Frequency not reported: Hyperglycemia, anorexia^[Ref]

Dermatologic

Frequency not reported: Sweating^[Ref]