Note: This document contains side effect information about icatibant. Some dosage forms listed on this page may not apply to the brand name Firazyr.
Summary
Common side effects of Firazyr include: hematoma at injection site, injection site reaction, urticaria at injection site, bruising at injection site, burning sensation at injection site, erythema at injection site, irritation at injection site, pain at injection site, and swelling at injection site. Continue reading for a comprehensive list of adverse effects.
Applies to icatibant: subcutaneous solution.
Serious side effects of Firazyr
Along with its needed effects, icatibant (the active ingredient contained in Firazyr) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking icatibant:
Less common
- Fever
Other side effects of Firazyr
Some side effects of icatibant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
Less common
- Dizziness
Incidence not known
- Headache
- nausea
- rash
For Healthcare Professionals
Applies to icatibant: subcutaneous solution.
General
The most common adverse reactions were injection site reactions, pyrexia, transaminase increased, dizziness, and rash.[Ref]
Local
Very common (10% or more): Injection site reaction (97%)[Ref]
Injection site reaction includes bruising, hematoma, burning, erythema, hypoesthesia, irritation, numbness, edema, pain, pressure sensation, pruritus, swelling, urticaria, or warmth at the site of injection.[Ref]
Dermatologic
Common (1% to 10%): Rash, pruritus, erythema
Uncommon (0.1% to 1%): Generalized urticaria[Ref]
Respiratory
Common (1% to 10%): Nasopharyngitis, nasal congestion
Uncommon (0.1% to 1%): Pharyngitis, asthma, cough[Ref]
Gastrointestinal
Common (1% to 10%): Gastroenteritis, nausea
Uncommon (0.1% to 1%): Vomiting[Ref]
Nervous system
Common (1% to 10%): Dizziness, headache[Ref]
Other
Common (1% to 10%): Pyrexia
Uncommon (0.1% to 1%): Asthenia, fatigue, contusion[Ref]
Hepatic
Common (1% to 10%): Transaminase increased
Uncommon (0.1% to 1%): Liver function test abnormal[Ref]
Hematologic
Common (1% to 10%): Prothrombin time prolonged[Ref]
Renal
Common (1% to 10%): Blood creatinine phosphokinase increased[Ref]
Metabolic
Uncommon (0.1% to 1%): Weight increased, blood glucose increased, hyperuricemia, hyperglycemia[Ref]
Immunologic
Uncommon (0.1% to 1%): Herpes zoster
Frequency not reported: Anti-icatibant (the active ingredient contained in Firazyr) antibodies[Ref]
Cardiovascular
Uncommon (0.1% to 1%): Hot flush[Ref]
Genitourinary
Uncommon (0.1% to 1%): Proteinuria[Ref]
Musculoskeletal
Uncommon (0.1% to 1%): Muscle spasm[Ref]
