Note: This document contains side effect information about alendronate. Some dosage forms listed on this page may not apply to the brand name Fosamax.
Summary
Common side effects of Fosamax include: decreased serum calcium and decreased serum phosphate. Other side effects include: arthralgia, myalgia, and ostealgia. Continue reading for a comprehensive list of adverse effects.
Applies to alendronate: oral solution, oral tablet, oral tablet effervescent.
Serious side effects of Fosamax
Along with its needed effects, alendronate (the active ingredient contained in Fosamax) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking alendronate:
More common
- Stomach pain
Less common
- Difficulty with swallowing
- heartburn
- irritation or pain of the esophagus
- muscle pain
Rare
- Skin rash
Incidence not known
- Blistering, peeling, or loosening of the skin
- bloating or swelling of the face, arms, hands, lower legs, or feet
- bone, joint, or muscle pain, severe and occasionally incapacitating
- chest pain
- chills
- confusion
- convulsions
- cough
- diarrhea
- difficulty with breathing
- difficulty with moving
- heartburn
- heavy jaw feeling
- hives or welts
- irregular heartbeats
- itching
- joint pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loosening of a tooth
- muscle aching or cramping
- muscle cramps in the hands, arms, feet, legs, or face
- numbness and tingling around the mouth, fingertips, or feet
- pain or burning in the throat
- pain, swelling, or numbness in the mouth or jaw
- rapid weight gain
- red skin lesions, often with a purple center
- red, irritated eyes
- redness of the skin
- sore throat
- sores, ulcers, or white spots on the lips or tongue or inside the mouth
- stomach cramps
- swollen joints
- tingling of the hands or feet
- tremor
- trouble breathing
- unusual tiredness or weakness
- unusual weight gain or loss
- vomiting
Other side effects of Fosamax
Some side effects of alendronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Constipation
- diarrhea
- full or bloated feeling
- gas
- headache
- nausea
Incidence not known
- Blurred vision or other change in vision
- dizziness or lightheadedness
- eye pain
- feeling of constant movement of self or surroundings
- general feeling of discomfort or illness
- hair loss or thinning of the hair
- sensation of spinning
- sensitivity of the eye to light
- tearing
For Healthcare Professionals
Applies to alendronate: oral solution, oral tablet, oral tablet effervescent.
General
Generally, this drug has been well tolerated. Adverse effects usually have been mild when patients adhered to prescribing instructions.[Ref]
Musculoskeletal
Very common (10% or more): Bone, muscle or joint pain (sometimes severe)
Common (1% to 10%): Muscle cramp, joint swelling
Rare (less than 0.1%): Osteonecrosis of the jaw, atypical subtrochanteric and diaphyseal femoral fractures
Postmarketing reports: Myalgia, low-energy femoral shaft and subtrochanteric fractures[Ref]
Dermatologic
Common (1% to 10%): Alopecia, pruritus
Uncommon (0.1% to 1%): Rash, erythema
Rare (less than 0.1%): Rash with photosensitivity, severe skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis[Ref]
Gastrointestinal
Common (1% to 10%): Abdominal pain, dyspepsia, acid regurgitation, nausea, abdominal distension, constipation, diarrhea, flatulence, esophageal ulcer, gastritis, gastroesophageal reflux
Uncommon (0.1% to 1%): Gastric ulcer, esophagitis, esophageal erosions, melena, dysphagia, vomiting
Rare (less than 0.1%): Esophageal stricture, oropharyngeal ulceration, upper gastrointestinal PUB (perforation, ulcers, bleeding)
Postmarketing reports: Localized osteonecrosis of the jaw, generally associated with tooth extraction and/or local infection with delayed healing[Ref]
Nervous system
Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Dysgeusia[Ref]
Other
Common (1% to 10%): Vertigo, asthenia, peripheral edema
Uncommon (0.1% to 1%): Transient symptoms of myalgia, malaise and rarely, typically in association with initiation of treatment[Ref]
Ocular
Uncommon (0.1% to 1%): Eye inflammation (uveitis, scleritis, episcleritis)[Ref]
Metabolic
Rare (less than 0.1%): Symptomatic hypocalcemia (often in association with predisposing conditions)[Ref]
Hypersensitivity
Rare (less than 0.1%): Urticaria, angioedema[Ref]
Respiratory
Postmarketing reports: Acute asthma exacerbations[Ref]
