Summary
Commonly reported side effects of glycerol phenylbutyrate include: dizziness, fatigue, headache, nausea, and vomiting. Continue reading for a comprehensive list of adverse effects.
Applies to glycerol phenylbutyrate: oral solution.
Serious side effects
Along with its needed effects, glycerol phenylbutyrate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking glycerol phenylbutyrate:
More common
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- chills
- confusion
- continuing nausea or vomiting
- cough
- decreased urination
- dizziness
- drowsiness
- dry mouth
- fainting
- fever
- heartburn
- increase in heart rate
- increase in the frequency of seizures
- lightheadedness
- loss of appetite
- lower back or side pain
- muscle tremors
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- rapid breathing
- rapid, deep breathing
- restlessness
- sore throat
- stomach cramps
- sunken eyes
- swollen glands
- thirst
- troubled breathing with exertion
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- wrinkled skin
Other side effects
Some side effects of glycerol phenylbutyrate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Agitation
- bloated or full feeling
- constipation
- diarrhea
- excess air or gas in the stomach or bowels
- headache
- irritability
- passing gas
- rash
- stomach pain
- stuffy or runny nose
- upper abdominal or stomach pain
Less common
- Belching
- indigestion
- stomach discomfort or upset
Incidence not known
- Abnormal body, skin, hair, and urine odor
- burning sensation in the mouth
- dry heaves
- gagging
- loss of or change in taste
For Healthcare Professionals
Applies to glycerol phenylbutyrate: oral liquid.
General
The most frequently reported side effects included diarrhea, flatulence, and headache.[Ref]
Nervous system
Very common (10% or more): Headache (14%), dizziness[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (16%), flatulence (14%), upper abdominal pain (pediatric patients), nausea , vomiting
Common (1% to 10%): Abdominal pain (adults), dyspepsia
Postmarketing reports: Retching, gagging, burning sensation in mouth[Ref]
Metabolic
Very Common (10% or more): Decreased appetite, hyperammonemia[Ref]
Other
Common (1% to 10%): Fatigue[Ref]
Dermatologic
Very common (10% or more): Rash (pediatric patients)
Postmarketing reports: Abnormal body odor, including from skin, hair, and urine[Ref]
