Heart failure may affect cognitive health by impacting brain cells

Evan Walker
Evan Walker TheMediTary.Com |
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A calcium ‘leak’ in brain cells may be part of the mechanism involved in heart failure-related cognitive decline. Image credit: shunli zhao/Getty Images.
  • More than 64 million people globally have heart failure.
  • Cognitive impairment is a common complication in people with heart failure.
  • Researchers from Columbia University believe a small calcium leak inside the brain’s neurons is why heart failure may lead to cognitive decline.
  • Scientists have also developed an experimental drug aimed at ‘plugging’ the calcium leak to help slow heart failure progression.

Over 64 million people worldwide are impacted by heart failure — an incurable cardiovascular condition where the heart cannot efficiently pump blood throughout the body.

People with heart failure are at a higher risk for certain complications, including shortness of breath, arrhythmia, kidney issues, and fluid build-up in the lungs, abdomen, feet, and legs.

Additionally, cognitive impairment is a common complication in people with heart failure.

Now, researchers from Columbia University believe a small calcium leak inside the brain’s neurons may be why heart failure could lead to cognitive decline.

Additionally, scientists have developed an experimental drug to “plug” the calcium leak and potentially slow the progression of heart failure.

This study was recently published in the journal Nature Neuroscience.

MNT also spoke with Dr. Richard Wright, a cardiologist at Providence Saint John’s Health Center in Santa Monica, CA, not involved in the research, about this study.

He commended the investigators on finally coming up with a grand unifying theory of different disease states, which has been in the works for decades.

“It’s been known for many years that people with chronic heart failure are weak and they have trouble breathing,” Dr. Wright explained. “And, as was pointed out in this article, frequently they have cognitive dysfunction compared to their peers.”

“Here Dr. Marks’ team is trying to come up with a unifying theory to explain all these different changes that occur in heart failure patients and I think they’ve struck the mark. I think this concept that calcium overload is a unifying mechanism to explain not only the heart’s dysfunction, but skeletal muscle dysfunction, diaphragm dysfunction, and as the point of the article, brain dysfunction as well, I buy into it.”

– Dr. Richard Wright

Dr. Wright commented he was very excited to hear about a compound developed in the research team’s laboratory that has been shown to beneficially affect these changes.

“We’re at the dawn of a new era and that era is what I would call designer molecules,” he said. “We’ve already seen it now in amyloidosis, we’ve seen it in hypertrophic cardiomyopathy, where you can design molecules that alter pathologic changes of proteins.“

“They have these substances developed in their lab that help circumvent these changes that help avert the calcium overload inside the neurons in the brain and inside the heart cells and inside skeletal muscle cells that could make a huge impact on the outcomes of our patients.”

However, Dr. Wright did state more research still needs to be conducted as most of the data in this article was from a mouse model.

“Sometimes we get misled because humans are not mice,” he added. “But they’ve done a very good job of trying to circumvent that and going to the trouble of using pieces of brains from autopsies to prove their point, which I think is very real.”

Other study limitations include the fact that the sample of human brains analyzed by the researchers was small, and that the control group in this study was made out of participants much younger than the individuals who had experienced heart failure and cognitive decline.

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