Note: This document contains side effect information about hydrochlorothiazide / losartan. Some dosage forms listed on this page may not apply to the brand name Hyzaar.
Summary
More frequent side effects include: dizziness. Continue reading for a comprehensive list of adverse effects.
Applies to hydrochlorothiazide / losartan: oral tablet.
Warning
Oral route (Tablet)
Drugs that act directly on the renin-angiotensin system can cause injury or death to the developing fetus. Stop therapy as soon as possible when pregnancy is detected.
Serious side effects of Hyzaar
Along with its needed effects, hydrochlorothiazide/losartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / losartan:
Rare
- Black, tarry stools
- blood in the urine or stools
- cough or hoarseness accompanied by chills or fever, lower back or side pain, or painful or difficult urination
- fainting
- pinpoint red spots on the skin
- pounding heartbeat
- severe stomach pain, nausea, and vomiting
- skin rash
- swelling of the feet or lower legs
- unusual bleeding or bruising
Incidence not known
- Bleeding gums
- blistering, peeling, loosening of the skin
- blurred vision
- chest pain or tightness
- chills
- coma
- confusion
- cough
- dark-colored urine
- decreased frequency of urine
- decreased urine output
- diarrhea
- difficulty swallowing
- dizziness
- dry mouth
- fast, irregular, pounding, or racing heartbeat or pulse
- fever
- hives, itching skin, rash
- increased sensitivity of the skin to sunlight
- increased thirst
- irritability
- joint or muscle pain
- large, flat, blue, or purplish patches in the skin
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- light-colored stools
- loss of appetite
- lower back or side pain
- muscle cramps, pain, spasms, stiffness, or twitching
- nausea or vomiting
- numbness or tingling in the hands, feet, or lips
- painful knees and ankles
- persistent non-healing sore
- pink growth
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- raised red swellings on the skin, the buttocks, legs, or ankles
- red, irritated eyes
- red skin lesions, often with a purple center
- reddish patch or irritated area
- redness or other discoloration of the skin
- restlessness
- seizures
- severe sunburn
- shiny bump
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- swelling of the face, ankles, or hands
- trouble breathing
- upper right abdominal or stomach pain
- unusual tiredness or weakness
- weak or irregular heartbeat
- weight gain
- white, yellow or waxy scar-like area
- yellow eyes and skin
Other side effects of Hyzaar
Some side effects of hydrochlorothiazide / losartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Body aches or pain
- headache
- loss of voice
- sneezing
- sore throat
- stuffy or runny nose
Rare
- Dry cough
Incidence not known
- Acid or sour stomach
- belching
- change or loss of taste
- difficulty having a bowel movement (stool)
- general feeling of discomfort or illness
- heartburn
- inability to have or keep an erection
- indigestion
- loss in sexual ability, desire, drive, or performance
- trouble sleeping
- weight loss
For Healthcare Professionals
Applies to hydrochlorothiazide / losartan: oral tablet.
General
The most common adverse reaction was dizziness.[Ref]
Nervous system
Common (1% to 10%): Dizziness, headache
Losartan:
Frequency not reported: Syncope, cerebrovascular accident, ataxia, hypesthesia, memory impairment, migraine, paresthesia, peripheral neuropathy, somnolence, vertigo, tremor, taste perversion, tinnitus[Ref]
Respiratory
Common (1% to 10%): Cough, sinusitis, upper respiratory infection, bronchitis, pharyngitis
Hydrochlorothiazide:
Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema
Losartan:
Frequency not reported: Dyspnea, epistaxis, nasal congestion, pharyngeal discomfort, respiratory congestion, rhinitis, sinus disorder
Postmarketing reports: Dry cough[Ref]
Gastrointestinal
Common (1% to 10%): Abdominal pain, diarrhea, nausea
Hydrochlorothiazide:
Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation
Losartan:
Frequency not reported: Constipation, dental pain, dry mouth, dyspepsia, flatulence, gastritis, vomiting[Ref]
Cardiovascular
Common (1% to 10%): Palpitation, essential hypertension
Uncommon (0.1% to 1%): Hypotension
Hydrochlorothiazide:
Frequency not reported: Vasculitis
Losartan:
Frequency not reported: Angina pectoris, arrhythmias, atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation, hypotension, myocardial infarction, second degree atrioventricular block, flushing
Postmarketing reports: Vasculitis[Ref]
Other
Common (1% to 10%): Edema/swelling, asthenia/fatigue
Hydrochlorothiazide:
Frequency not reported: Weakness, fever
Losartan:
Frequency not reported: Chest pain, facial edema, fever, orthostatic effects, malaise[Ref]
Dermatologic
Common (1% to 10%): Rash
Hydrochlorothiazide:
Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis
Losartan:
Common (1% to 10%): Rash
Frequency not reported: Angioedema, superficial peeling of palms, alopecia, dermatitis, dry skin, ecchymosis, erythema, photosensitivity, pruritus, sweating, urticaria
Postmarketing reports: Erythroderma[Ref]
Musculoskeletal
Common (1% to 10%): Back pain
Hydrochlorothiazide:
Frequency not reported: Muscle spasm
Losartan:
Frequency not reported: Arm pain, arthralgia, arthritis, fibromyalgia, hip pain, joint swelling, knee pain, leg pain, muscle cramps, muscle weakness, musculoskeletal pain, myalgia, shoulder pain, stiffness
Postmarketing reports: Rhabdomyolysis[Ref]
Renal
Uncommon (0.1% to 1%): Serum creatinine increased greater than 5 mg/dL, BUN increased
Hydrochlorothiazide:
Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis
Losartan:
Common (1% to 10%): Serum creatinine increased greater than 5 mg/dL[Ref]
Hepatic
Frequency not reported: Liver enzymes elevated, serum bilirubin elevated
Postmarketing reports: Hepatitis
Hydrochlorothiazide:
Frequency not reported: Intrahepatic cholestatic jaundice
Losartan:
Postmarketing reports: Hepatitis[Ref]
Hematologic
Frequency not reported: Hemoglobin decreased, hematocrit decreased
Hydrochlorothiazide:
Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia
Losartan:
Frequency not reported: Hemolysis, anemia[Ref]
Metabolic
Postmarketing reports: Hyperkalemia
Hydrochlorothiazide:
Frequency not reported: Hyperglycemia, hyperuricemia
Losartan:
Frequency not reported: Anorexia, gout
Postmarketing reports: Hyperkalemia, hyponatremia[Ref]
Ocular
Hydrochlorothiazide:
Frequency not reported: Transient blurred vision, xanthopsia
Losartan:
Frequency not reported: Blurred vision, burning/stinging in the eye, conjunctivitis, visual acuity decreased[Ref]
Psychiatric
Hydrochlorothiazide:
Frequency not reported: Restlessness
Losartan:
Frequency not reported: Anxiety, anxiety disorder, confusion, dream abnormality, depression, insomnia, libido decreased, nervousness, panic disorder, sleep disorder[Ref]
Genitourinary
Hydrochlorothiazide:
Frequency not reported: Glycosuria
Losartan:
Frequency not reported: Impotence, nocturia, urinary frequency, urinary tract infection[Ref]
Immunologic
Losartan:
Postmarketing reports: Anaphylactic reactions[Ref]
