Excipient (pharmacologically inactive substance)

What is it?

Diethyl phthalate (C12H14O4), or DEP is a diethyl ester of phthalic acid. DEP is used as a plasticizer in consumer goods, including plastic packaging films, cosmetics, solvent for fragrances, a surface lubricant in food and pharmaceutical packaging, and in tubing used for medical purposes. It is a colorless, oily liquid.^[1]

There are concerns about the toxicity of phthalates in consumer products and the environment. Exposure to DEP can occur through inhalation, ingestion, eye or skin contact. Some studies suggest little toxicity, but other research has identified reproductive toxicity in animal studies.^[2]

According to a document published by the Centers for Disease Control and Prevention (CDC) for occupational safety, diethyl phthalate has irritant effects on the eyes, skin, and mucous membranes and can lead to central nervous system (CNS) effects in exposed workers. CNS effects only occurred in exposed workers after 6 to 7 years of chronic exposure to phthalates.^[3]