Note: This document contains side effect information about mecasermin rinfabate. Some dosage forms listed on this page may not apply to the brand name iPlex.

Applies to mecasermin rinfabate: subcutaneous solution.

Endocrine

Endocrine side effects have included hypoglycemia, hyperglycemia, tonsilar hypertrophy, adenoid hypertrophy, lymphadenopathy, and thyromegaly.^[Ref]

Local

Local side effects have included erythema, lipohypertrophy and hair growth at the injection sites.^[Ref]

Ocular

Ocular side effects have included papilledema, possibly due to increased intracranial pressure.^[Ref]

Nervous system

Nervous system side effects have included headaches.^[Ref]

Hepatic

Hepatic side effects have included increases in liver size, and increased transaminase (AST) and LDH levels,^[Ref]

Hematologic

Hematologic side effects have included iron deficiency anemia and increased size of the spleen.^[Ref]

Musculoskeletal

Musculoskeletal side effects have included arthralgia, bone pain, muscular atrophy, and pain in an extremity.^[Ref]

Renal

Renal side effects have included increases in kidney size.^[Ref]

Genitourinary

Genitourinary side effects have included ovarian cysts.^[Ref]

Cardiovascular

Cardiovascular side effects have included echographic evidence of valvulopathy.^[Ref]