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Home > Drugs > First generation cephalosporins > Keflex > Keflex Side Effects
First generation cephalosporins

Keflex Side Effects

Note: This document contains side effect information about cephalexin. Some dosage forms listed on this page may not apply to the brand name Keflex.

Applies to cephalexin: oral capsules, oral for suspension.

Side effects include:

Adverse GI effects, including diarrhea, nausea, vomiting, dyspepsia, gastritis, abdominal pain.

For Healthcare Professionals

Applies to cephalexin: oral capsule, oral powder for reconstitution, oral tablet, oral tablet dispersible.

General

The most commonly reported side effects included diarrhea, dyspepsia, gastritis, nausea, and vomiting.[Ref]

Gastrointestinal

Frequency not reported: Diarrhea, nausea, vomiting, dyspepsia, gastritis, abdominal pain, anal pruritus, Clostridium difficile-associated diarrhea/colitis/pseudomembranous colitis

Postmarketing reports: Colitis[Ref]

Hematologic

Frequency not reported: Direct Coombs' test seroconversion, decreased prothrombin activity/prolonged prothrombin time, eosinophilia, neutropenia, thrombocytopenia, hemolytic anemia

Postmarketing reports: Aplastic anemia, pancytopenia, leukopenia, agranulocytosis[Ref]

Dermatologic

Frequency not reported: Urticaria, rash, erythema multiforme, Stevens Johnson syndrome, toxic epidermal necrolysis/exanthematic necrolysis[Ref]

Hepatic

Frequency not reported: Transient hepatitis, cholestatic jaundice, AST and ALT elevations

Postmarketing reports: Increased bilirubin[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity/allergic reactions, angioedema, anaphylaxis[Ref]

Allergic reactions (including urticaria and angioedema) usually subsided upon treatment discontinuation.[Ref]

Genitourinary

Frequency not reported: Genital pruritus, genital candidiasis, vulvovaginitis/vaginitis and vaginal discharge[Ref]

Nervous system

Frequency not reported: Seizure, dizziness, headache[Ref]

Psychiatric

Frequency not reported: Agitation, confusion, hallucinations[Ref]

Musculoskeletal

Frequency not reported: Arthralgia, arthritis, joint disorder[Ref]

Renal

Frequency not reported: Reversible interstitial nephritis

Postmarketing reports: Renal dysfunction, toxic nephropathy, increased blood urea nitrogen, increased creatinine[Ref]

Other

Frequency not reported: Fatigue

Postmarketing reports: Fever[Ref]

Immunologic

Frequency not reported: Development of drug-resistant bacteria development[Ref]

Metabolic

Postmarketing reports: Increased alkaline phosphatase, increased lactate dehydrogenase (LDH)[Ref]

Cardiovascular

Postmarketing reports: Hemorrhage[Ref]

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