Note: This document contains side effect information about chlorambucil. Some dosage forms listed on this page may not apply to the brand name Leukeran.

Applies to chlorambucil: oral tablets.

Side effects include:

Bone marrow suppression.

For Healthcare Professionals

Applies to chlorambucil: compounding powder, oral tablet.

Hematologic

Very common (10% or more): Leukopenia, neutropenia, thrombocytopenia, pancytopenia, bone marrow suppression

Common (1% to 10%): Anemia

Very rare (less than 0.01%): Irreversible bone marrow failure^[Ref]

Nervous system

Common (1% to 10%): Convulsions in children with nephrotic syndrome

Rare (0.01% to 0.1%): Convulsions, partial and/or generalized in children and adults, ataxia, flaccid paresis

Very rare (less than 0.01%): Movement disorders (e.g., tremor, muscle twitching, myoclonus in the absence of convulsions, peripheral neuropathy^[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash

Rare (less than 0.1%): Stevens-Johnson syndrome, toxic epidermal necrolysis

Frequency not reported: Urticaria, angioneurotic edema, skin hypersensitivity (including rare reports of skin rash progressing to erythema multiforme)^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, diarrhea, mouth ulceration^[Ref]

Respiratory

Very rare (less than 0.01%): Interstitial pulmonary fibrosis, interstitial pneumonia^[Ref]

Hepatic

Rare (less than 0.1%): Hepatotoxicity, jaundice^[Ref]

Genitourinary

Very rare (less than 0.01%): Sterile cystitis

Frequency not reported: Amenorrhea, azoospermia, infertility^[Ref]

Oncologic

Common (1% to 10%): Acute secondary hematologic malignancies (especially leukemia and myelodysplastic syndrome), particularly after long term therapy^[Ref]

Psychiatric

Rare (less than 0.1%): Confusion, agitation, hallucinations^[Ref]

Musculoskeletal

Frequency not reported: Tremors, muscular twitching, myoclonia

Other

Rare (less than 0.1%): Pyrexia