Applies to liothyronine: oral tablet. Other dosage forms:

• intravenous solution

Serious side effects of Liothyronine

Along with its needed effects, liothyronine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking liothyronine:

Incidence not known

• Anxiety
• arm, back, or jaw pain
• blurred or double vision
• chest pain or discomfort
• chest tightness or heaviness
• crying
• decreased bone mineral density
• decreased urine output
• delusions of persecution, mistrust, suspiciousness, or combativeness
• diarrhea
• difficulty breathing
• dilated neck vein
• dizziness
• excessive
• sweating
• extreme tiredness or weakness
• eye pain
• fainting
• false or unusual sense of well-being
• fast, pounding, or irregular heartbeat or pulse
• feeling of discomfort
• feeling of unreality
• fever
• headache
• heat intolerance
• impaired fertility
• increased appetite
• increased blood pressure
• irregular breathing
• irritability
• itching, skin rash
• joint swelling
• limp pain in the hip or knee
• menstrual changes
• mental depression
• muscle aches, weakness, or cramps
• nausea
• nervousness
• pain or discomfort in the arms, jaw, back, or neck
• quick to react or overreact emotionally
• rapidly changing moods
• restlessness
• sense of detachment from self or body
• severe headache
• slow heartbeat
• stomach cramps
• swelling of the face, fingers, feet, or lower legs
• swollen lymph glands
• tremors
• trouble sitting still
• trouble sleeping
• vomiting
• weight gain or loss

Get emergency help immediately if any of the following symptoms of overdose occur while taking liothyronine:

Symptoms of overdose

• Cold, clammy skin
• confusion about identity, place, and time
• difficulty in speaking
• dizziness
• double vision
• fast, weak pulse
• headache
• inability to move the arms, legs, or facial muscles
• inability to speak
• lightheadedness
• loss of consciousness
• nervousness
• seizure
• sensitivity to heat
• slow speech
• sweating
• trouble sleeping
• weight loss

Other side effects of Liothyronine

Some side effects of liothyronine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Feeling of warmth
• hair loss
• redness of the face, neck, arms, and occasionally, upper chest

For Healthcare Professionals

Applies to liothyronine: compounding powder, intravenous solution, oral tablet.

General

Reported side effects are usually indicative of excessive dosage and will usually disappear when the dose is reduced or treatment is stopped.^[Ref]

Cardiovascular

Common (1% to 10%): Arrhythmia, tachycardia, cardiopulmonary arrest, hypotension, myocardial infarction

Frequency not reported: Angina, congestive heart failure, hypertension, flushing, palpitation^[Ref]

Nervous system

Frequency not reported: Headache, tremor, benign intracranial hypertension^[Ref]

Dermatologic

Frequency not reported: Allergic skin reaction, sweating, rash pruritus, transient hair loss^[Ref]

Musculoskeletal

Frequency not reported: Twitching, muscle cramps, muscle weakness, craniostenosis, premature closure of epiphysis^[Ref]

Gastrointestinal

Frequency not reported: Diarrhea, vomiting^[Ref]

Immunologic

Frequency not reported: Hypersensitivity reaction^[Ref]

Local

Frequency not reported: Phlebitis^[Ref]

Psychiatric

Frequency not reported: Restlessness, excitability, insomnia^[Ref]

Genitourinary

Frequency not reported: Menstruation irregular^[Ref]

Other

Frequency not reported: Fever, edema, weight loss, heat intolerance^[Ref]