Note: This document contains side effect information about atorvastatin / ezetimibe. Some dosage forms listed on this page may not apply to the brand name Liptruzet.

Applies to atorvastatin / ezetimibe: oral tablet.

General

The more commonly reported adverse reactions have included increased ALT, increased AST, and musculoskeletal pain.^[Ref]

Hepatic

Common (1% to 10%): ALT increased (5%), AST increased (4%)

Postmarketing reports: Hepatitis, cholelithiasis, cholecystitis, fatal and nonfatal hepatic failure^[Ref]

Musculoskeletal

Common (1% to 10%): Musculoskeletal pain (3.8 to 4%), arthralgia (3 to 6.9%), pain in extremity (2.7 to 6%), myalgia (3.5%), muscle spasms (3%), muscle weakness (2%)

Postmarketing reports: Myopathy/rhabdomyolysis, necrotizing myopathy (rarely), injury, poisoning and procedural complication, tendon rupture, myositis^[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea (4.1 to 6.8%), abdominal pain (3%), nausea (3 to 4%), dyspepsia (4.7%)^[Ref]

Nervous system

Common (1% to 10%): Dizziness (2 to 6%), insomnia (3%), fatigue (2.4%)

Postmarketing reports: Headache, paraesthesia, peripheral neuropathy, amnesia, memory impairment, confusion, depression, dizziness^[Ref]

Metabolic

Common (1% to 10%): Hyperkalemia (2%)^[Ref]

Endocrine

Common (1% to 10%): Hot flushes (2%)^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection (5.7%)^[Ref]

Hematologic

Postmarketing reports: Thrombocytopenia, elevated creatine phosphokinase^[Ref]

Hypersensitivity

Postmarketing reports: Anaphylaxis, hypersensitivity reactions^[Ref]

Immunologic

Common (1% to 10%): Influenza (2%)^[Ref]

Respiratory

Common (1% to 10%): Coughing (2 to 3%), bronchitis (2%), sinusitis (2 to 2.8%), upper respiratory tract infection (4.3%), nasopharyngitis (up to 8.3%), pharyngolaryngeal pain (up to 2.3%)

Postmarketing reports: Interstitial lung disease^[Ref]

Other

Postmarketing reports: Fatigue

Dermatologic

Postmarketing reports: Angioedema, bullous rashes (including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis), rash, urticaria^[Ref]