Note: This document contains side effect information about fospropofol. Some dosage forms listed on this page may not apply to the brand name Lusedra.

Applies to fospropofol: intravenous solution.

Respiratory

Very common (10% or more): Hypoxemia (up to 11%)

Common (1% to 10%): Procedural pain (bronchoscopy)

Uncommon (0.1% to 1%): Apnea^[Ref]

Nervous system

-Paresthesia includes the following terms: paresthesia genital male; burning sensation; genital burning sensation; vaginal burning sensation; skin burning sensation; genital pain (reported as burning); perineal pain (reported as burning); anal discomfort (reported as burning); chest pain (reported as burning); ear discomfort (reported as burning); nasal discomfort (reported as burning); buttock pain (reported as stinging); groin pain (reported as stinging); pain (reported as stinging); sensory disturbance (reported as nonspecific sensation in pubic area).

-Pruritus includes the following terms: genital pruritus female; genital pruritus male; pruritus genital; pruritus ani; pruritus generalized.

-Paresthesias (including burning, tingling, stinging) and/or pruritus, usually manifested in the perineal region, were the most frequently recorded adverse reactions in clinical trials. Paresthesias and pruritus generally occurred within 5 minutes after administration of the initial dose and were generally transient and mild to moderate in intensity. The pharmacologic basis of these sensory phenomena is unknown. No pretreatments, including the use of nonsteroidal anti-inflammatory drugs, opioids, or lidocaine, are known to have an effect on or to reduce the incidence of these sensations.^[Ref]

Very common (10% or more): Paresthesia (up to 74%)

Common (1% to 10%): Headache^[Ref]

Cardiovascular

Common (1% to 10%): Hypotension^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting^[Ref]

Other

Common (1% to 10%): Procedural pain^[Ref]

Dermatologic

Very common (10% or more): Pruritus (up to 28%)^[Ref]