Applies to lutetium lu 177 dotatate: intravenous solution.
Serious side effects
Along with its needed effects, lutetium lu 177 dotatate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking lutetium lu 177 dotatate:
More common
- Agitation
- anxiety
- black, tarry stools
- bleeding gums
- blood in the urine or stools
- blurred vision
- chills
- cold sweats
- confusion
- cool, pale skin
- cough
- decreased urine output
- diarrhea
- difficulty in breathing
- dizziness
- dry mouth
- feeling of warmth
- fever
- flushed, dry skin
- fruit-like breath odor
- headache
- hoarseness
- hostility
- increased hunger
- increased thirst
- increased urination
- irritability
- joint pain, stiffness, or swelling
- loss of appetite
- loss of consciousness
- lower back, side, arm, leg, or stomach pain
- mood changes
- mood or mental changes
- muscle cramps in the hands, arms, feet, legs, or face
- muscle pain or twitching
- nausea
- nervousness
- nightmares
- numbness and tingling around the mouth, lips, hands, fingertips, or feet
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- pounding in the ears
- rapid weight gain
- redness of the face, neck, arms, and occasionally, upper chest
- restlessness
- seizures
- shakiness
- slow, fast, or irregular heartbeat
- slurred speech
- sore throat
- sweating
- swelling of the face, feet, lower legs, ankles, or hands
- tremor
- troubled breathing
- troubled breathing with exertion
- ulcers, sores, or white spots in the mouth
- unexplained weight loss
- unusual bleeding or bruising
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- vomiting
- weakness or heaviness of the legs
Less common
- Bone pain
- chest pain or discomfort
- dilated neck veins
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- extreme tiredness or weakness
- irregular breathing
- pain or discomfort in the arms, jaw, back, or neck
- swollen glands
Other side effects
Some side effects of lutetium lu 177 dotatate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Constipation
- decreased appetite
- hair loss or thinning of the hair
- loss or change in taste
Less common
- Difficulty in moving
- neck pain
For Healthcare Professionals
Applies to lutetium lu 177 dotatate: intravenous solution.
Hematologic
Common (1% to 10%): Lymphopenia, leukopenia, neutropenia, thrombocytopenia, anemia[Ref]
Musculoskeletal
Common (1% to 10%): Back pain, pain in extremity, myalgia, neck pain[Ref]
Metabolic
Common (1% to 10%): Decreased appetite, hyperglycemia, hypocalcemia, hypokalemia, hyperkalemia, hypernatremia, hypoglycemia[Ref]
Psychiatric
Common (1% to 10%): Anxiety[Ref]
Hepatic
Common (1% to 10%): GGT increased, alkaline phosphatase increased, AST increased, ALT increased, blood bilirubin increased[Ref]
Respiratory
Common (1% to 10%): Cough[Ref]
Other
Common (1% to 10%): Fatigue, peripheral edema, pyrexia[Ref]
Nervous system
Common (1% to 10%): Headache, dizziness, dysgeusia[Ref]
Renal
Common (1% to 10%): Renal failure (glomerular filtration rate decreased, acute kidney injury, acute prerenal failure, azotemia, renal disorder, renal failure, renal impairment); hyperuricemia; creatinine increased[Ref]
Cardiovascular
Common (1% to 10%): Atrial fibrillation, flushing, hypertension[Ref]
Dermatologic
Common (1% to 10%): Alopecia
Gastrointestinal
Common (1% to 10%): Nausea, vomiting abdominal pain, diarrhea, constipation[Ref]
Genitourinary
Common (1% to 10%): Radiation related urinary tract toxicity (dysuria, micturition urgency, nocturia, pollakiuria, renal colic, renal pain, urinary tract pain and urinary incontinence)
