Applies to margetuximab: intravenous solution.
Warning
Intravenous route (Solution)
Warning: Left Ventricular Dysfunction and Embryo-fetal ToxicityLeft Ventricular Dysfunction: Margetuximab-cmkb may lead to reductions in left ventricular ejection fraction (LVEF). Evaluate cardiac function prior to and during treatment. Discontinue margetuximab-cmkb treatment for a confirmed clinically significant decrease in left ventricular function.Embryo-fetal Toxicity: Exposure to margetuximab-cmkb during pregnancy can cause embryo-fetal harm. Advise patients of the risk and need for effective contraception.
Serious side effects of Margetuximab
Along with its needed effects, margetuximab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking margetuximab:
More common
- Back pain
- chest pain or tightness
- chills
- cough
- decreased urine output
- difficulty in moving
- dilated neck veins
- fever
- flushing
- headache
- irregular breathing
- irregular heartbeat
- muscle aches, cramps, pain, or stiffness
- nausea and vomiting
- pain in the joints
- redness, swelling, pain of the skin
- scaling of the skin on the hands and feet
- swelling of the face, fingers, feet, or lower legs
- swollen joints
- tingling of the hands and feet
- trouble breathing
- ulceration of the skin
- unusual tiredness or weakness
- weakness
- weight gain
Other side effects of Margetuximab
Some side effects of margetuximab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Arm or leg pain
- burning, numbness, tingling, or painful sensations
- constipation
- decreased appetite
- diarrhea
- hair loss, thinning of hair
- stomach pain
- unsteadiness or awkwardness
- weakness in the arms, hands, legs, or feet
For Healthcare Professionals
Applies to margetuximab: intravenous solution.
Hematologic
Very common (10% or more): Decreased hemoglobin (52%;), decreased leukocytes (40%), decreased lymphocytopenia (31%), increased INR (24%;), increased aPTT (32%)
Common (1% to 10%): Febrile neutropenia (1.5%), neutropenia/neutrophil count decrease (1.5%)[Ref]
Immunologic
Common (1% to 10%): Immunogenicity (1.7%)[Ref]
Musculoskeletal
Very common (10% or more): Myalgia (14%), arthralgia (14%), extremity pain (11%)[Ref]
Hepatic
Very common (10% or more): Increased serum alanine aminotransferase (32%), increased serum aspartate aminotransferase (23%), increased serum alkaline phosphatase (21%)[Ref]
Respiratory
Very common (10% or more): Cough (14%), dyspnea (13%)
Uncommon (0.1% to 1%): Aspiration pneumonia (0.4%), viral pneumonia(0.8%)[Ref]
General
Very common (10% or more): Fatigue/Asthenia (57%), pyrexia (19%), infusion related reaction (13%)
Common (1% to 10%): Fatal adverse reactions (1.1%)[Ref]
Nervous system
Very common (10% or more): Headache (19%), peripheral neuropathy (16%)
Common (1% to 10%): Dizziness (10%), insomnia (6%)[Ref]
Renal
Very common (10% or more): Increased serum creatinine (68%)[Ref]
Cardiovascular
Common (1% to 10%): Hypertension (5%), left ventricular dysfunction (1.9%), syncope (1.5%)[Ref]
Dermatologic
Very common (10% or more): Alopecia (18%), palmar-plantar erythrodysesthesia (13%)
Common (1% to 10%): Skin rash (6%)[Ref]
Endocrine
Common (1% to 10%): Decreased weight (6%), increased serum lipase (30%),[Ref]
Gastrointestinal
Very common (10% or more): Abdominal pain (17%), constipation (19%), increased serum lipase (30%), decreased appetite (14%), nausea (33%), vomiting (21%), diarrhea (25%)
Common (1% to 10%): Dysgeusia (6%), stomatitis (10%)[Ref]
