Applies to mechlorethamine topical: topical application gel/jelly.

Serious side effects

Along with its needed effects, mechlorethamine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mechlorethamine topical:

More common

• Blistering, crusting, irritation, itching, or reddening of the skin
• cracked, dry, scaly skin
• pain, swelling, tenderness, or warmth on the skin

Other side effects

Some side effects of mechlorethamine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Darkening of the skin

For Healthcare Professionals

Applies to mechlorethamine topical: topical gel.

Dermatologic

Very common (10% or more): Dermatitis (56%), pruritus (20%), bacterial skin infection (11%)

Common (1% to 10%): Skin ulceration or blistering, skin hyperpigmentation^[Ref]

Hematologic

Very common (10% or more): Reductions in hemoglobin, neutrophil count, or platelet count (13%)^[Ref]

Oncologic

Common (1% to 10%): Nonmelanoma skin cancer^[Ref]

Ocular

Frequency not reported: Eye pain, burns, inflammation, photophobia, blurred vision, blindness, irreversible anterior eye injury^[Ref]

General

The most common adverse reactions (5% or greater) are dermatitis, pruritus, bacterial skin infection, skin ulceration or blistering, and hyperpigmentation^[Ref]