I have been on bupropion XL 300mg for many years. Recently my pharmacy's switched the generic brand from slate run to rising pharmaceuticals. I felt the State Run brand was actually the best I'd ever taken. Since being on the rising brand I think I'm noticing negative effects and, currently, inexplicable bloating/abdominal distension. I can't be certain it's due to this different brand, but it does roughly correlate with when this issue started. Has anyone heard of either brand, and could there, in fact, be a quality difference to this extent? I really have not felt as good on the rising brand and never really believed in the notion that the manufacturer could make that much of a difference in generics, but I'm starting to wonder. Would greatly appreciate any input/advice! Thanks.