Eylea injections into the eye (intravitreal) are associated with a substantial but temporary increase in blood pressure in some patients.

One study of 201 patients reported that 72% of patients (n=144) had a mean systolic blood pressure increase of 10 mmHg or more and 46% (n=93) had a systolic BP increase of 20 mmHg or more. 11% (23 patients) had their blood pressure increase to over 200 mmHg which is associated with an increased risk of cardiovascular and cerebrovascular events. Blood pressure returned to near baseline levels approximately 5 minutes after the injection. The mean pulse rate also increased from 76 bpm to 80 bpm.

Consider perioperative blood pressure monitoring or increased antihypertensive treatment in people at high risk for cardiovascular or cerebrovascular events undergoing intravitreal Eylea injections.