High blood pressure (hypertension) and low blood pressure (hypotension) are not listed as side effects of Xarelto (rivaroxaban), a direct oral anticoagulant (DOAC) and factor Xa inhibitor used to treat and prevent blood clots.

However, Xarelto is a blood thinner and its use is associated with an increased risk of bleeding, which can be serious and may lead to death. If Xarelto causes excessive bleeding it can cause a sudden drop or decrease in your blood pressure and shock. Signs of shock include dizziness, weakness, confusion, anxiety, rapid breathing, pale skin and reduced urine output.

Shock caused by excessive bleeding occurs when there isn’t enough blood flow in your body, which results in your organs not getting enough nutrients and oxygen to work properly.

Xarelto may also cause severe allergic reactions (hypersensitivity), which can also result in a sudden drop in blood pressure. Other symptoms of a severe allergic reaction include hives and breathing difficulties, difficulty swallowing, and swelling of the face, lips, mouth, tongue or throat.