Epclusa stays in your system approximately 3 days after the last dose. This is calculated by looking at the half-life of velpatasvir which is 15 hours and that of sofosbuvir, which is 0.5 hours. The half-life is the time it takes for 50% of a medicine to be eliminated from the body. Research has shown that it takes 4 to 5 half-lives for a medicine to be fully cleared from the body which calculates out to 60 to 75 hours or 2.5 to 3.1 days for Epclusa. There are no active metabolites of velpatasvir or sofosbuvir that may prolong this half-life, and its clearance is not significantly affected by liver disease or mild-to-moderate kidney impairment.

If you are still experiencing side effects from Epclusa more than 5 days after you have stopped taking it, talk with your doctor. It can take a while for your body to recover from hepatitis C once you have finished a course of Epclusa. Talk to your doctor if you have any concerns.