Fetzima takes approximately 60 hours or 2.5 days to leave your system following the last dose. Experts calculate this period using the half-life of a drug. A drug’s half-life is the time it takes for 50% of that drug to be removed from the body. The half-life of Fetzima is about 12 hours and experts agree that it takes up to 5 half-lives for a drug without active metabolites to be completely removed from the body. This calculates out to 60 hours for Fetzima. But it is better to talk to your doctor about tapering off the drug slowly, instead of just stopping it suddenly because this makes it less likely that your depression will recur. Always talk to your doctor before stopping a medicine.

Fetzima breaks down in the liver into metabolites, but these are all inactive. Both levomilnacipran (the active component of Fetzima) and its metabolites are excreted primarily by the kidneys.
Fetzima is an oral, extended-release capsule that may be used to treat moderate-to-severe depression in adults.