Clobetasol propionate may be used to treat moderate-to-severe eczema, psoriasis, and other skin conditions off-label, but should only be used for the shortest time possible. Treatment should not exceed two weeks for eczema/dermatitis or psoriasis and no more than 50 grams of cream or ointment should be used per week.

When used to treat lichen sclerosus, treatment may be required for up to 12 weeks. However, only a very small amount (0.5g) of clobetasol propionate is used once a day.

This is because clobetasol propionate is classed as a super potent corticosteroid. Using more cream or ointment than recommended, or applying clobetasol propionate for longer than two weeks for eczema or psoriasis, could lead to side effects such as skin thinning, and rarely, growth retardation in children, cataracts, glaucoma, or suppression of the hypothalamic-pituitary-adrenal axis.

Clobetasol propionate is supplied in tamper-evident tubes of 15g, 30g, 45 g, and 60 g. Common brand names for clobetasone propionate include Cormax, Embeline, and Temovate.

Clobetasol propionate is not recommended in children under 12 years of age and the area of skin being treated with clobetasol propionate should never be covered with occlusive bandages or dressings.