I have a question about depression medications. I have had major depression (and OCD) for over 15 years, and most Serotonin Reuptake Inhibitors weren't helping me. Then my doctor prescribed me Venlafaxine, and it's been the most helpful drug I have ever taken. Venlafaxine is a Serotonin and Norepinephrine Reuptake Inhibitor. I can only assume the inclusion of helping my Norepinephrine levels is what has made the difference!

But I also suffer from chronic migraines. And it's gotten really horrible lately. My doctor prescribed me Propranolol, a beta-blocker, to help with migraine prophylaxis. It seemed to help, but when I ran out and forgot to get more for a few days I had a noticeable upturn in mood.

I read that beta-blockers block the affects of epinephrine and norepinephrine. Is the Propranolol negating the norepinephrine reuptake of my Venlafaxine? Is it possible that the Propranolol could be worsening my depression?