What are the differences between Praluent and Repatha?

The differences between Repatha (evolocumab) and Praluent (alirocumab) are their active ingredients, dosage forms available, and the number of strengths available in syringe and pen forms.

Repatha has more treatment indications than Praluent:

Praluent can be used to treat only adults but Repatha can also treat children over 10 years old with specific indications.

For adults Praluent and Repatha have the same treatment indications:

• Preventing cardiovascular disease specifically for myocardial infarction, stroke, and unstable angina requiring hospitalization, in adults with established cardiovascular disease.
• Treating primary hyperlipidemia specifically for adults with primary hyperlipidemia to reduce low-density lipoprotein cholesterol (LDL-C). This includes patients with Heterozygous Familial Hypercholesterolemia [HeFH]). To be used with a change in diet, and can be used with or without other lipid lowering medications.
• Reduction of LDL-C for patients with Homozygous Familial Hypercholesterolemia (HoFH) to be used with a change in diet, and can be used with or without other lipid lowering therapies eg statins, ezetimibe, LDL apheresis.

For children Repatha can be used for:

• Patients 10 years or older who have HeFH can take Repatha in addition to change in diet and with other LDL-C lowering medications to lower LDL-C.
• Patients that are 10 years or older with who have HoFH can take Repatha with other LDL-C lowering therapies to lower LDL-C

Repatha has more dosage forms available than Praluent

Praluent has two dosage forms compared Repatha which has three dosage forms, this may make Repatha more convenient for some patients.
The dosage forms that Praluent and Repatha both have are:

• single-use prefilled syringe
• pre-filled pen

Repatha has a third dosage form which is:

• on-body infusor with prefilled cartridge

Praluent has more strengths available for syringe and pens than Repatha

Repatha has one strength available in syringe and pen compared to Praluent which has two strengths available, this means Praluent patients can have their dose adjusted.
Repatha single-use prefilled syringe and pre-filled pen are available in a strength of

• 140 mg/mL.

Praluent single-use prefilled syringe and pre-filled pen are available in strengths

• 75 mg/mL
• 150mg/mL

What do Repatha and Praluent have in common?

• They are both from the same drug class which is PCSK9
• They should both be used in conjunction with a diet aimed at reducing cholesterol and triglycerides.
• Repatha and Praluent can be used on their own or in conjunction with lipid-lowering therapies (e.g., statins, ezetimibe).
• Both Repatha and Praluent can also be used in conjunction with LDL apheresis when used for Homozygous Familial Hypercholesterolemia (HoFH).