Miderizone (tolperisone) is a centrally acting muscle relaxant. It’s widely available in Europe and Asia and is marketed under different brand names, including:

• Abbsa
• Atmosgen
• Arantoick
• Besnoline
• Isocalm
• Kineorl
• Menopatol
• Metosomin
• Minacalm
• Mideton
• Miodom
• Muscalm
• Musclex
• Musocalm
• Musolax
• Myderison
• Mydeton
• Mydocalm
• Naismeritin
• Tolisartine
• Tolson
• Topxol
• Tolfree
• Userm

Miderizone is used to treat muscle spasticity due to muscular, vascular or neurological disorders. It comes as a 50 mg or 150 mg tablet that’s taken by mouth. Miderizone is usually taken with food.
The typical dosages are:

• Adults: 50 mg to 150 mg, 3 times daily
• Children:
  • 5 years old and younger: 5 mg/kg daily in three divided doses
  • 6 to 14 years of age: 2 to 4 mg/kg daily in three divided doses

Side effects of Miderizone are usually mild and may include:

• Decreased urination
• Sleepiness
• Mood changes and confusion
• Increased thirst
• Decreased appetite
• Nausea, vomiting, diarrhea or stomach cramps
• Shortness of breath
• Swelling
• Weight gain
• Skin rash
• Dizziness
• Rectal bleeding
• Low potassium level

Tolperisone is not currently available in the United States. However, in 2017, Neurana Pharmaceuticals was granted approval to begin Phase 2 clinical studies of tolperisone in the United States.
Comparable centrally acting muscle relaxants currently available in the U.S. include:

• Baclofen
• Methocarbamol
• Tizanidine